Gosteva E V, Vasileva L V
Voronezh State Medical Academy named after N.N. Burdenko of the Ministry of Public Health of the Russian Federation, Studencheskaya St., 394036 Voronezh, Russia.
Kardiologiia. 2015 Feb;55(2):32-36.
We studied effect of therapy with fixed combination of lercanidipine and enalapril on 24-hour blood pressure (BP) profile in 34 elderly patients (mean age 76.4+/-5.2 years, 14 men, 20 women) with degree II hypertension. After clinical examination patients were given lercanidipine/enalapril combination (10/10 mg/day). The dose was increased to 10+20 mg/day when necessary. Assessment of efficacy was conducted on Rate of achievement of target BP [systolic (S) BP <150 mm HG, diastolic (D) BP<90 mmHg] and dynamics of parameters of 24-hour BP profile. Re-examinations were carried out on weeks 4.8 and 12 of treatment. Administration of lercanidipine/enalapril combination was associated with mean 24-hour SBP and DBP lowering (by15.3 and 8.7%, respectively). Diurnal and nocturnal SBP/DBP decreased by 15.7/ 9.2.
我们研究了乐卡地平与依那普利固定复方疗法对34例II级高血压老年患者（平均年龄76.4±5.2岁，男性14例，女性20例）24小时血压（BP）情况的影响。经临床检查后，给予患者乐卡地平/依那普利复方制剂（10/10毫克/天）。必要时将剂量增至10 + 20毫克/天。根据目标血压[收缩压（S）BP < 150毫米汞柱，舒张压（D）BP < 90毫米汞柱]的达标率以及24小时血压情况参数的动态变化来评估疗效。在治疗的第4、8和12周进行复查。使用乐卡地平/依那普利复方制剂使24小时平均收缩压和舒张压降低（分别降低15.3%和8.7%）。日间和夜间收缩压/舒张压分别降低了15.7/9.2。
