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[左心室室壁瘤患者电生理与灌注变化的相互关系]

[Interrelation of Electrophysiological and Perfusion Changes in Patients With Left Ventricular Aneurysm].

作者信息

Babokin V E, Shipulin V M, Minin S M, Batalov R E, Gutor S S, Lishmanov U B, Popov S V, Ilyinov V N, Andreev S L, Karpov R S

机构信息

1M.F. Vladimirsky Moscow Region Research Clinical Institute, Moscow, Russia; 2Research Institute for Cardiology, Tomsk, Russia; 3Siberian State Medical University, Tomsk, Russia.

出版信息

Kardiologiia. 2016 Apr;56(4):11-15. doi: 10.18565/cardio.2016.4.11-15.

Abstract

The study was aimed at identification of relations between perfusion and electrophysiological changes in left ventricular (LV) myocardium in patients with ischemic heart disease (IHD) with postinfarction LV aneurysm and ventricular tachycardia. The study enrolled 23 patients with the aforementioned disease. Preoperatively, apart from standard clinical examination of cardiosurgical patients, intracardiac electrophysiological study and perfusion single-photon emission computed tomography of myocardium with 99mTc-Technetril were performed. The patients were subjected to coronary artery bypass grafting and left ventricular reconstruction. Assessment of the outcomes showed that electrophysiological condition of left ventricle was dependent on myocardial perfusion. Electrophysologically normal myocardium with electric potential >1.5 mV, transient zone (0.5-1.5 mV) and zones with the potential <0.5 mV differed significantly by the percentage of perfusion: 61, 45, and 35%, respectively. Zones of delayed conduction and those of double potential were located mostly in transient zone of electrical potential conduction with the current amplitude of 0.5-1.5 mV and myocardial perfusion from 35 to 61%. Double potential zone was formed in the area of myocardium with better perfusion (perfusion defect of 55% with preserved metabolism) as opposed to the zone of delayed conduction, where perfusion defect was 40% with low level of metabolic activity. The obtained data has proven the presence of correlation between electrophysiology and perfusion of myocardium. This provides an opportunity to identify electrically unstable myocardial zones with the help of specific computer tomography of myocardium.

摘要

该研究旨在确定患有心肌梗死后左心室动脉瘤和室性心动过速的缺血性心脏病(IHD)患者左心室(LV)心肌灌注与电生理变化之间的关系。该研究纳入了23例患有上述疾病的患者。术前,除了对心脏外科手术患者进行标准临床检查外,还进行了心内电生理研究和用99mTc-替奈曲尔进行的心肌灌注单光子发射计算机断层扫描。患者接受了冠状动脉搭桥术和左心室重建。结果评估表明,左心室的电生理状况取决于心肌灌注。电位>1.5 mV的电生理正常心肌、过渡区(0.5 - 1.5 mV)和电位<0.5 mV的区域在灌注百分比方面有显著差异:分别为61%、45%和35%。传导延迟区和双电位区大多位于电位传导的过渡区,电流幅度为0.5 - 1.5 mV,心肌灌注为35%至61%。与传导延迟区相比,双电位区形成于心肌灌注较好的区域(代谢保留时灌注缺损为55%),传导延迟区的灌注缺损为40%,代谢活性水平较低。所获得的数据证明了心肌电生理与灌注之间存在相关性。这为借助特定的心肌计算机断层扫描识别电不稳定心肌区域提供了机会。

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