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对单胎妊娠无症状女性实施普遍宫颈长度筛查:挑战与机遇

Implementing universal cervical length screening in asymptomatic women with singleton pregnancies: challenges and opportunities.

作者信息

Pedretti Michelle K, Kazemier Brenda M, Dickinson Jan E, Mol Ben W J

机构信息

School of Women's and Infants' Health, The University of Western Australia, Perth, Western Australia, Australia.

Department of Obstetrics and Gynaecology, Academic Medical Centre, Amsterdam, The Netherlands.

出版信息

Aust N Z J Obstet Gynaecol. 2017 Apr;57(2):221-227. doi: 10.1111/ajo.12586. Epub 2017 Mar 10.

Abstract

Cervical length (CL) screening has been successfully utilised to identify asymptomatic women, with a singleton pregnancy, at risk of preterm birth (PTB), thereby providing an opportunity to offer interventions that may reduce that risk. Cervical length screening with ultrasound is most effectively performed with a transvaginal approach. Universal cervical length screening, encompassing all singleton pregnancies rather than restricting screening to those considered at increased risk of PTB, is currently not widely used, despite a growing body of evidence in support of its utility for PTB prevention. There are a number of barriers that may prevent or restrict the implementation of a universal CL screening program. These include cost, availability of vaginal progesterone and other treatment options, reluctance of women to undergo transvaginal ultrasound and the perceptions and beliefs of medical practitioners. Given that mid-pregnancy CL measurement is a recognised predictor of spontaneous PTB, that most cases of PTB occur with no prior maternal history and that there are interventions available that may reduce the risk of PTB, we believe there is a clear role for routine CL screening to be adopted as a component of the fetal morphology ultrasound examination. As a strategy to reduce PTB rates, discussion and counselling about PTB prevention and CL screening should be adopted as a core element of prenatal care.

摘要

宫颈长度(CL)筛查已成功用于识别单胎妊娠且有早产(PTB)风险的无症状女性,从而提供了一个机会来实施可能降低该风险的干预措施。经阴道超声进行宫颈长度筛查最为有效。尽管越来越多的证据支持其在预防PTB方面的效用,但目前普遍的宫颈长度筛查(涵盖所有单胎妊娠,而非仅对那些被认为PTB风险增加的孕妇进行筛查)并未广泛应用。存在一些可能阻碍或限制普遍CL筛查项目实施的障碍。这些障碍包括成本、阴道孕酮及其他治疗方案的可获得性、女性不愿接受经阴道超声检查以及医生的观念和信念。鉴于孕中期CL测量是自发性PTB的公认预测指标,大多数PTB病例并无先前的母亲病史,且存在可降低PTB风险的干预措施,我们认为常规CL筛查作为胎儿形态超声检查的一部分具有明确作用。作为降低PTB发生率的一项策略,关于PTB预防和CL筛查的讨论及咨询应作为产前护理的核心要素。

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