JES Tech, NASA-Johnson Space Center, Houston, Texas.
Wyle Science, Technology and Engineering Group, Houston, Texas.
J Med Virol. 2017 Sep;89(9):1686-1689. doi: 10.1002/jmv.24807. Epub 2017 May 2.
Varicella zoster virus (VZV) in saliva from six herpes zoster patients and one chickenpox patient was found to be exclusively associated with epithelial cells by confocal microscopy. VZV localization with antibody specific to the VZV glycoprotein E was detected primarily on the membrane but was also inside the cell. Epithelial cells with VZV were still present in saliva in one out of two tested zoster patients after 10 months of recovery. Saliva from healthy controls (non-shingles patients, n = 5) did not show any sign of VZV by polymerase chain reaction or by confocal microscopy. No VZV was found in the liquid fraction of saliva. Further work is required to understand the movement of VZV in the saliva cells of infected patients.
通过共聚焦显微镜发现，6 例带状疱疹患者和 1 例水痘患者的唾液中的水痘带状疱疹病毒 (VZV) 仅与上皮细胞有关。用针对 VZV 糖蛋白 E 的抗体进行的 VZV 定位主要在细胞膜上，但也在细胞内。在 2 例带状疱疹患者中，有 1 例在康复 10 个月后，唾液中仍存在具有 VZV 的上皮细胞。通过聚合酶链反应或共聚焦显微镜，来自健康对照者（非带状疱疹患者，n=5）的唾液均未显示任何 VZV 迹象。唾液的液体部分也未发现 VZV。需要进一步研究以了解感染患者唾液中的 VZV 运动情况。
