Ozcan L, Polat E C, Kocaaslan R, Onen E, Otunctemur A, Ozbek E
Department of Urology, Derince Training and Research Hospital, Kocaeli, Turkey.
Department of Urology, Okmeydani Training and Research Hospital, Istanbul, Turkey.
Andrologia. 2017 Nov;49(9). doi: 10.1111/and.12751. Epub 2017 Mar 15.
We aimed to evaluate the efficacy of tadalafil 5 mg once-daily treatment on testosterone levels in patients with erectile dysfunction (ED) accompanied by the metabolic syndrome. A total of 40 men with metabolic syndrome were evaluated for ED in this study. All the patients received 5 mg tadalafil once a day for 3 months. Erectile function was assessed using the five-item version of the International Index of Erectile Function (IIEF) questionnaire. Serum testosterone, follicle-stimulating hormone and luteinising hormone levels were also evaluated, and blood samples were taken between 08.00 and 10.00 in the fasting state. All participants have three or more criteria of metabolic syndrome. At the end of 3 months, mean testosterone values and IIEF scores showed an improvement from baseline values (from 3.6 ± 0.5 to 5.2 ± 0.3, from 11.3 ± 1.9 to 19 ± 0.8 respectively). After the treatment, serum LH levels were decreased (from 5.6 ± 0.6 to 4.6 ± 0.5). There was significantly difference in terms of baseline testosterone and luteinising hormone values and IIEF scores (p < .05). Based on our findings, we recommend tadalafil 5 mg once daily in those men with erectile dysfunction especially low testosterone levels accompanied by metabolic syndrome.
我们旨在评估每日一次服用5毫克他达拉非对伴有代谢综合征的勃起功能障碍（ED）患者睾酮水平的疗效。本研究共评估了40名患有代谢综合征的男性的ED情况。所有患者每天服用5毫克他达拉非，持续3个月。使用国际勃起功能指数（IIEF）问卷的五项版本评估勃起功能。还评估了血清睾酮、促卵泡激素和黄体生成素水平，并在禁食状态下于08:00至10:00采集血样。所有参与者都有三项或更多代谢综合征标准。3个月末，平均睾酮值和IIEF评分较基线值有所改善（分别从3.6±0.5提高到5.2±0.3，从11.3±1.9提高到19±0.8）。治疗后，血清LH水平降低（从5.6±0.6降至4.6±0.5）。基线睾酮和黄体生成素值以及IIEF评分存在显著差异（p<0.05）。基于我们的研究结果，我们建议对于伴有代谢综合征的勃起功能障碍男性，尤其是睾酮水平低的患者，每日一次服用5毫克他达拉非。
