Department of Biomedical Engineering, Cornell University, Ithaca, New York, USA.
Department of Radiology, Weill Cornell Medical College, New York, New York, USA.
Magn Reson Med. 2018 Jan;79(1):172-179. doi: 10.1002/mrm.26657. Epub 2017 Mar 10.
The objective of this study was to demonstrate the feasibility of a cerebral metabolic rate of oxygen (CMRO ) mapping method based on its minimum local variance (MLV) without vascular challenge using quantitative susceptibility mapping (QSM) and cerebral blood flow (CBF).
Three-dimensional multi-echo gradient echo imaging and arterial spin labeling were performed in 11 healthy subjects to calculate QSM and CBF. Minimum local variance was used to compute whole-brain CMRO map from QSM and CBF. The MLV method was compared with a reference method using the caffeine challenge. Their agreement within the cortical gray matter (CGM) was assessed on CMRO and oxygen extraction fraction (OEF) maps at both baseline and challenge states.
Mean CMRO (in µmol/100 g/min) obtained in CGM using the caffeine challenge and MLV were 142 ± 16.5 and 139 ± 14.8 µmol/100 g/min, respectively; the corresponding baseline OEF were 33.0 ± 4.0% and 31.8 ± 3.2%, respectively. The MLV and caffeine challenge methods showed no statistically significant differences across subjects with small ( < 4%) biases in CMRO and OEF values.
Minimum local variance-based CMRO mapping without vascular challenge using QSM and arterial spin labeling is feasible in healthy subjects. Magn Reson Med 79:172-179, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
本研究旨在展示一种基于最小局部方差（MLV）的脑氧代谢率（CMRO ）映射方法的可行性，该方法无需血管挑战，使用定量磁化率映射（QSM）和脑血流（CBF）。
11 名健康受试者进行三维多回波梯度回波成像和动脉自旋标记，以计算 QSM 和 CBF。使用最小局部方差从 QSM 和 CBF 计算全脑 CMRO 图。将 MLV 方法与使用咖啡因挑战的参考方法进行比较。在基线和挑战状态下，在皮质灰质（CGM）内评估其在 CMRO 和氧摄取分数（OEF）图上的一致性。
使用咖啡因挑战和 MLV 在 CGM 中获得的平均 CMRO（以 µmol/100g/min 计）分别为 142±16.5 和 139±14.8 µmol/100g/min；相应的基线 OEF 分别为 33.0±4.0%和 31.8±3.2%。MLV 和咖啡因挑战方法在受试者之间没有显示出统计学上的显著差异，CMRO 和 OEF 值的偏差较小（ < 4%）。
使用 QSM 和动脉自旋标记无需血管挑战的基于最小局部方差的 CMRO 映射在健康受试者中是可行的。磁共振医学 79：172-179，2018。© 2017 国际磁共振学会。
