喉软骨放射性坏死：威斯康星大学24年的经验
Chondroradionecrosis of the larynx: 24-year University of Wisconsin experience.
作者信息
Gessert Thomas G, Britt Christopher J, Maas Austin M W, Wieland Aaron M, Harari Paul M, Hartig Gregory K
机构信息
Division of Otolaryngology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
出版信息
Head Neck. 2017 Jun;39(6):1189-1194. doi: 10.1002/hed.24749. Epub 2017 Mar 11.
BACKGROUND
Chondroradionecrosis (CRN) is an uncommon but significant complication of laryngeal radiotherapy that presents a diagnostic challenge to clinicians through its similarity in presentation to cancer recurrence.
METHODS
Two hundred ninety-four patients underwent primary, adjuvant, or salvage radiation for laryngeal cancer from 1991 to 2015 at the University of Wisconsin. Medical records were reviewed to identify and characterize patients with a diagnosis of CRN.
RESULTS
Of the 294 patients, 7 cases (2.4%) of CRN were identified. Development of CRN was associated with the presence of cartilage invasion by tumor (p = .038) and ongoing alcohol use postradiotherapy (p = .036). Additionally, a trend between development of CRN and ongoing smoking postradiotherapy was observed (p = .067).
CONCLUSION
The diagnosis of CRN is challenging, and the likelihood of successful resolution is modest. A high premium should be placed on efforts directed at prevention, such as tobacco and alcohol cessation. © 2017 Wiley Periodicals, Inc. Head Neck 39: 1189-1194, 2017.
背景
软骨放射性坏死（CRN）是喉癌放射治疗中一种不常见但严重的并发症，因其临床表现与癌症复发相似，给临床医生带来了诊断挑战。
方法
1991年至2015年期间，威斯康星大学有294例患者接受了喉癌的初次、辅助或挽救性放疗。回顾医疗记录以识别和描述诊断为CRN的患者。
结果
在这294例患者中，确诊7例（2.4%）CRN。CRN的发生与肿瘤侵犯软骨（p = 0.038）以及放疗后持续饮酒（p = 0.036）有关。此外，观察到CRN发生与放疗后持续吸烟之间存在一种趋势（p = 0.067）。
结论
CRN的诊断具有挑战性，成功解决的可能性不大。应高度重视预防措施，如戒烟戒酒。© 2017威利期刊公司。《头颈》39: 1189 - 1194, 2017。
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