Mallory Melissa A, Sagara Yasuaki, Aydogan Fatih, DeSantis Stephen, Jayender Jagadeesan, Caragacianu Diana, Gombos Eva, Vosburgh Kirby G, Jolesz Ferenc A, Golshan Mehra
Department of Surgery, Brigham and Women's Hospital/Harvard Medical School, Dana-Farber Cancer Institute, Boston, Massachusetts.
Breast Oncology Center, Dana-Farber Cancer Institute, Boston, Massachusetts.
Breast J. 2017 Nov;23(6):713-717. doi: 10.1111/tbj.12796. Epub 2017 Mar 10.
We assessed the feasibility of supine intraoperative MRI (iMRI) during breast-conserving surgery (BCS), enrolling 15 patients in our phase I trial between 2012 and 2014. Patients received diagnostic prone MRI, BCS, pre-excisional supine iMRI, and postexcisional supine iMRI. Feasibility was assessed based on safety, sterility, duration, and image-quality. Twelve patients completed the study; mean duration = 114 minutes; all images were adequate; no complications, safety, or sterility issues were encountered. Substantial tumor-associated changes occurred (mean displacement = 67.7 mm, prone-supine metric, n = 7). We have demonstrated iMRI feasibility for BCS and have identified potential limitations of prone breast MRI that may impact surgical planning.
我们评估了保乳手术（BCS）期间仰卧位术中磁共振成像（iMRI）的可行性，在2012年至2014年期间，我们的I期试验纳入了15名患者。患者接受了俯卧位诊断性MRI、BCS、切除前仰卧位iMRI和切除后仰卧位iMRI。基于安全性、无菌性、持续时间和图像质量评估可行性。12名患者完成了研究；平均持续时间=114分钟；所有图像均足够；未遇到并发症、安全性或无菌性问题。发生了与肿瘤相关的显著变化（平均位移=67.7毫米，俯卧位-仰卧位测量，n=7）。我们已经证明了iMRI用于BCS的可行性，并确定了俯卧位乳腺MRI可能影响手术规划的潜在局限性。
