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急性特发性周围性面神经麻痹患者的住院治疗:一项基于人群的医疗保健研究。

Inpatient treatment of patients with acute idiopathic peripheral facial palsy: A population-based healthcare research study.

作者信息

Plumbaum K, Volk G F, Boeger D, Buentzel J, Esser D, Steinbrecher A, Hoffmann K, Jecker P, Mueller A, Radtke G, Witte O W, Guntinas-Lichius O

机构信息

Department of Otorhinolaryngology, Jena University Hospital, Jena, Germany.

Facial Nerve Center Jena, Jena University Hospital, Jena, Germany.

出版信息

Clin Otolaryngol. 2017 Dec;42(6):1267-1274. doi: 10.1111/coa.12862. Epub 2017 Apr 2.

Abstract

OBJECTIVES

To determine the inpatient management for patients with acute idiopathic facial palsy (IFP) in Thuringia, Germany.

DESIGN

Population-based study.

SETTING

All inpatients with IFP in all hospitals with departments of otolaryngology and neurology in 2012, in the German federal state, Thuringia.

MAIN OUTCOME MEASURES

Patients' characteristics and treatment were compared between departments, and the probability of recovery was tested.

RESULTS

A total of 291 patients were mainly treated in departments of otolaryngology (55%) and neurology (36%). Corticosteroid treatment was the predominant therapy (84.5%). The probability to receive a facial nerve grading (odds ratio [OR=12.939; 95% confidence interval [CI]=3.599 to 46.516), gustatory testing (OR=6.878; CI=1.064 to 44.474) and audiometry (OR=32.505; CI=1.485 to 711.257) was significantly higher in otolaryngology departments, but lower for cranial CT (OR=0.192; CI=0.061 to 0.602), cerebrospinal fluid examination (OR=0.024; CI=0.006 to 0.102). A total of 131 patients (45%) showed a recovery to House-Brackmann grade≤II. A pathological stapedial reflex test (Hazard ratio [HR]=0.416; CI=0.180 to 0.959) was the only independent diagnostic predictor of worse outcome. Prednisolone dose >500 mg (HR=0.579; CI 0.400 to 0.838) and no adjuvant physiotherapy (HR=0.568; CI=0.407 to 0.794) were treatment-related predictors of worse outcome.

CONCLUSIONS

Inpatient treatment of IFP seems to be highly variable in daily practice, partly depending on the treating discipline and despite the availability of evidence-based guidelines. The population-based recovery rate was worse than reported in clinical trials.

摘要

目的

确定德国图林根州急性特发性面神经麻痹(IFP)患者的住院治疗情况。

设计

基于人群的研究。

背景

2012年德国图林根州所有设有耳鼻喉科和神经科的医院中所有IFP住院患者。

主要观察指标

比较各科室患者的特征和治疗情况,并测试恢复的可能性。

结果

共有291例患者主要在耳鼻喉科(55%)和神经科(36%)接受治疗。皮质类固醇治疗是主要治疗方法(84.5%)。在耳鼻喉科接受面神经分级(优势比[OR]=12.939;95%置信区间[CI]=3.599至46.516)、味觉测试(OR=6.878;CI=1.064至44.474)和听力测定(OR=32.505;CI=1.485至711.257)的可能性显著更高,但进行头颅CT(OR=0.192;CI=0.061至0.602)、脑脊液检查(OR=0.024;CI=0.006至0.102)的可能性更低。共有131例患者(45%)恢复至House-Brackmann分级≤II级。镫骨肌反射试验异常(风险比[HR]=0.416;CI=0.180至0.959)是预后较差的唯一独立诊断预测因素。泼尼松龙剂量>500 mg(HR=0.579;CI 0.400至0.838)和未进行辅助物理治疗(HR=0.568;CI=0.407至0.794)是与治疗相关的预后较差的预测因素。

结论

在日常实践中,IFP的住院治疗似乎差异很大,部分取决于治疗学科,尽管有循证指南。基于人群的恢复率比临床试验报告的更差。

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