玻璃体内注射自体“干细胞”治疗年龄相关性黄斑变性后的视力丧失
Vision Loss after Intravitreal Injection of Autologous "Stem Cells" for AMD.
作者信息
Kuriyan Ajay E, Albini Thomas A, Townsend Justin H, Rodriguez Marianeli, Pandya Hemang K, Leonard Robert E, Parrott M Brandon, Rosenfeld Philip J, Flynn Harry W, Goldberg Jeffrey L
机构信息
From the Department of Ophthalmology, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami (A.E.K., T.A.A., J.H.T., M.R., P.J.R., H.W.F.), and the Center for Sight, Sarasota (M.B.P.) - both in Florida; the Department of Ophthalmology, Flaum Eye Institute, University of Rochester Medical Center, Rochester, NY (A.E.K.); the Department of Ophthalmology, Dean McGee Eye Institute, University of Oklahoma, Oklahoma City (H.K.P., R.E.L.); and the Department of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, CA (J.L.G.).
出版信息
N Engl J Med. 2017 Mar 16;376(11):1047-1053. doi: 10.1056/NEJMoa1609583.
Adipose tissue-derived "stem cells" have been increasingly used by "stem-cell clinics" in the United States and elsewhere to treat a variety of disorders. We evaluated three patients in whom severe bilateral visual loss developed after they received intravitreal injections of autologous adipose tissue-derived "stem cells" at one such clinic in the United States. In these three patients, the last documented visual acuity on the Snellen eye chart before the injection ranged from 20/30 to 20/200. The patients' severe visual loss after the injection was associated with ocular hypertension, hemorrhagic retinopathy, vitreous hemorrhage, combined traction and rhegmatogenous retinal detachment, or lens dislocation. After 1 year, the patients' visual acuity ranged from 20/200 to no light perception.
在美国和其他地方，“干细胞诊所”越来越多地使用脂肪组织来源的“干细胞”来治疗各种疾病。我们评估了三名患者，他们在美国的一家这样的诊所接受玻璃体内注射自体脂肪组织来源的“干细胞”后出现了严重的双侧视力丧失。在这三名患者中，注射前最后一次用斯内伦视力表记录的视力范围为20/30至20/200。注射后患者的严重视力丧失与高眼压、出血性视网膜病变、玻璃体积血、牵引性和孔源性视网膜脱离合并症或晶状体脱位有关。1年后，患者的视力范围为20/200至无光感。
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