Fang J, Cui L Y, Liu M S, Guan Y Z, Ding Q Y, Du H, Li B H, Wu S
Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100730, China.
Zhonghua Yi Xue Za Zhi. 2017 Mar 7;97(9):670-674. doi: 10.3760/cma.j.issn.0376-2491.2017.09.007.
The study aimed to investigate whether sample sizes of F-wave study differed according to different nerves, different F-wave parameters, and amyotrophic lateral sclerosis(ALS) patients or healthy subjects. The F-waves in the median, ulnar, tibial, and deep peroneal nerves of 55 amyotrophic lateral sclerosis (ALS) patients and 52 healthy subjects were studied to assess the effect of sample size on the accuracy of measurements of the following F-wave parameters: F-wave minimum latency, maximum latency, mean latency, F-wave persistence, F-wave chronodispersion, mean and maximum F-wave amplitude. A hundred stimuli were used in F-wave study. The values obtained from 100 stimuli were considered "true" values and were compared with the corresponding values from smaller samples of 20, 40, 60 and 80 stimuli. F-wave parameters obtained from different sample sizes were compared between the ALS patients and the normal controls. Significant differences were not detected with samples above 60 stimuli for chronodispersion in all four nerves in normal participants. Significant differences were not detected with samples above 40 stimuli for maximum F-wave amplitude in median, ulnar and tibial nerves in normal participants. When comparing ALS patients and normal controls, significant differences were detected in the maximum (median nerve, =-3.560, <0.01; ulnar nerve, =5.019, <0.01; tibial nerve, =-2.475, <0.05; peroneal nerve, =-2.088, <0.05)and mean F-wave latency (median nerve, =-3.243, <0.01; ulnar nerve, =3.876, <0.01; tibial nerve, =-2.206, <0.05; peroneal nerve, =-2.205, <0.05)in all four nerves, F-wave chronodispersion (=-3.152, <0.01)in the ulnar nerve, F-wave persistence in the median (=6.139, <0.01)and ulnar nerves(=5.350, <0.01), mean F-wave amplitude in the tibial nerve(=2.981, <0.01), maximum F-wave amplitude in the ulnar (=-2.134, <0.05)and tibial nerves (=2.746, <0.01)with 20 stimuli; for chronodispersion in tibial nerve (=2.551, <0.05)100 stimuli, for chronodispersion in peroneal nerve (=-2.086, <0.05)80 stimuli, for F-wave persistence in tibial nerve (=2.119, <0.05) 60 stimuli, for mean F-wave amplitude in ulnar (=-2.552, <0.05)and peroneal nerve (=-2.228, <0.05)40 stimuli, for maximum F-wave amplitude in peroneal nerve (=2.693, <0.01)60 stimuli were necessary to detect differences. Sample sizes of F-wave study differed according to different nerves, different F-wave parameters , and ALS patients or healthy subjects.
本研究旨在调查F波研究的样本量是否因不同神经、不同F波参数以及肌萎缩侧索硬化症（ALS）患者或健康受试者而有所不同。对55例肌萎缩侧索硬化症（ALS）患者和52例健康受试者的正中神经、尺神经、胫神经和腓深神经的F波进行研究，以评估样本量对以下F波参数测量准确性的影响：F波最小潜伏期、最大潜伏期、平均潜伏期、F波出现率、F波时限离散度、平均F波幅和最大F波幅。F波研究中使用100次刺激。将从100次刺激获得的值视为“真实”值，并与来自20、40、60和80次刺激的较小样本的相应值进行比较。比较了ALS患者和正常对照中不同样本量获得的F波参数。在正常受试者中，对于所有四条神经的时限离散度，刺激次数超过60次时未检测到显著差异。在正常受试者中，对于正中神经、尺神经和胫神经的最大F波幅，刺激次数超过40次时未检测到显著差异。在比较ALS患者和正常对照时，在所有四条神经的最大（正中神经，=-3.560，<0.01；尺神经，=5.019，<0.01；胫神经，=-2.475，<0.05；腓神经，=-2.088，<0.05）和平均F波潜伏期（正中神经，=-3.243，<0.01；尺神经，=3.876，<0.01；胫神经，=-2.206，<0.05；腓神经，=-2.205，<0.05）、尺神经的F波时限离散度（=-3.152，<0.01）、正中神经（=6.139，<0.01）和尺神经（=5.350，<0.01）的F波出现率、胫神经的平均F波幅（=2.981，<0.01）、尺神经（=-2.134，<0.05）和胫神经（=2.746，<0.01）的最大F波幅方面，20次刺激时检测到显著差异；对于胫神经的时限离散度（=2.551，<0.05），100次刺激；对于腓神经的时限离散度（=-2.086，<0.05），80次刺激；对于胫神经的F波出现率（=2.119，<0.05），60次刺激；对于尺神经（=-2.552，<0.05）和腓神经（=-2.228，<0.05）的平均F波幅，40次刺激；对于腓神经的最大F波幅（=2.693，<0.01），60次刺激时才能检测到差异。F波研究的样本量因不同神经、不同F波参数以及ALS患者或健康受试者而有所不同。
