VRK1 和下游基因 BANF1 在食管癌中的表达。
Expression of VRK1 and the downstream gene BANF1 in esophageal cancer.
机构信息
Department of Medical Laboratory, First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, 450052, China.
Department of Medical Laboratory, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, China.
出版信息
Biomed Pharmacother. 2017 May;89:1086-1091. doi: 10.1016/j.biopha.2017.02.095. Epub 2017 Mar 11.
Esophageal cancer is considered one of the most malignant tumors, being characterized by rapid progression and poor outcomes. China has the highest incidence of esophageal cancer in the world. Hence, it is necessary to clarify the mechanisms underlying esophageal cancer progression. In this study, we examined the expression of vaccinia-related kinase 1 (VRK1) and barrier to autointegration factor 1 (BANF1) in tumor tissues at the mRNA and protein levels via real-time PCR and immunohistochemical analyses. The mRNA and protein expression levels of VRK1 and BANF1 were higher in tumor tissues than in adjacent normal tissues. ROC curve analysis showed that VRK1 and BANF1 yielded AUCs of 0.790 and 0.735, respectively, for the detection of esophageal squamous cell carcinoma(ESCC) patients. In conclusion, our study indicates that VRK1 and BANF are promising novel therapeutic targets for esophageal cancer.
食管癌被认为是最恶性的肿瘤之一，其特点是进展迅速，预后不良。中国是世界上食管癌发病率最高的国家。因此，有必要阐明食管癌进展的机制。在这项研究中，我们通过实时 PCR 和免疫组织化学分析，检测了肿瘤组织中天花病毒相关激酶 1（VRK1）和自身整合因子 1 （BANF1）的 mRNA 和蛋白水平表达。VRK1 和 BANF1 的 mRNA 和蛋白表达水平在肿瘤组织中均高于相邻的正常组织。ROC 曲线分析表明，VRK1 和 BANF1 检测食管鳞状细胞癌（ESCC）患者的 AUC 分别为 0.790 和 0.735。综上所述，我们的研究表明，VRK1 和 BANF 是治疗食管癌有前途的新靶点。
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