苯二氮䓬受体拮抗剂Ro 15 - 1788对小鼠乙醇诱导的中毒无作用。
Lack of effect of the benzodiazepine receptor antagonist Ro 15-1788 on ethanol-induced intoxication in mice.
作者信息
Masur J, Silva-Filho A R, de Souza M L, Pires M L
机构信息
Departamento de Psicobiologia, Escola Paulista de Medicina, São Paulo, Brasil.
出版信息
Alcohol. 1987 Nov-Dec;4(6):425-7. doi: 10.1016/0741-8329(87)90079-6.
PMID:2829940
Abstract
The effects of 3, 6 and 48 mg/kg of the benzodiazepine receptor antagonist Ro 15-1788 on the ethanol-induced depressant action were evaluated in mice. These results support and extend previous findings in experimental animals and show that Ro 15-1788 in doses devoid of intrinsic effects, does not antagonize the motor impairment, hypnotic effect or lethality induced by ethanol.
摘要
在小鼠中评估了3、6和48mg/kg苯二氮䓬受体拮抗剂Ro 15 - 1788对乙醇诱导的抑制作用的影响。这些结果支持并扩展了先前在实验动物中的发现，表明在无内在效应剂量下的Ro 15 - 1788不能拮抗乙醇诱导的运动功能损害、催眠作用或致死性。
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