RUNX在缺氧诱导反应和血管生成中的作用。

Roles of RUNX in Hypoxia-Induced Responses and Angiogenesis.

作者信息

Lee Sun Hee, Manandhar Sarala, Lee You Mie

机构信息

National Basic Research Laboratory of Vascular Homeostasis Regulation, BK21 Plus KNU Multi-Omics based Creative Drug Research Team, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Kyungpook National University, Daegu, 41566, South Korea.

出版信息

Adv Exp Med Biol. 2017;962:449-469. doi: 10.1007/978-981-10-3233-2_27.

DOI:10.1007/978-981-10-3233-2_27

PMID:28299673

Abstract

During the past two decades, Runt domain transcription factors (RUNX1, 2, and 3) have been investigated in regard to their function, structural elements, genetic variants, and roles in normal development and pathological conditions. The Runt family proteins are evolutionarily conserved from Drosophila to mammals, emphasizing their physiological importance. A hypoxic microenvironment caused by insufficient blood supply is frequently observed in developing organs, growing tumors, and tissues that become ischemic due to impairment or blockage of blood vessels. During embryonic development and tumor growth, hypoxia triggers a stress response that overcomes low-oxygen conditions by increasing erythropoiesis and angiogenesis and triggering metabolic changes. This review briefly introduces hypoxic conditions and cellular responses, as well as angiogenesis and its related signaling pathways, and then describes our current knowledge on the functions and molecular mechanisms of Runx family proteins in hypoxic responses, especially in angiogenesis.

摘要

在过去二十年中，人们对Runt结构域转录因子（RUNX1、2和3）的功能、结构元件、基因变异以及它们在正常发育和病理状况中的作用进行了研究。Runt家族蛋白从果蝇到哺乳动物在进化上是保守的，这突出了它们的生理重要性。在发育中的器官、生长的肿瘤以及因血管损伤或阻塞而缺血的组织中，经常会观察到由于血液供应不足导致的缺氧微环境。在胚胎发育和肿瘤生长过程中，缺氧会引发一种应激反应，通过增加红细胞生成和血管生成以及触发代谢变化来克服低氧状况。本综述简要介绍了缺氧条件和细胞反应，以及血管生成及其相关信号通路，然后描述了我们目前关于Runx家族蛋白在缺氧反应，特别是在血管生成中的功能和分子机制的认识。