Restaino Stephen M, Berger Adam, White Ian M
Fischell Department of Bioengineering, University of Maryland, 2216 Jeong H. Kim Engr. Building, College Park, MD, 20742, USA.
Methods Mol Biol. 2017;1572:525-540. doi: 10.1007/978-1-4939-6911-1_33.
Surface enhanced Raman spectroscopy (SERS) provides rapid and sensitive identification of small molecule analytes. Traditionally, fabrication of SERS devices is an expensive process that involves the use of micro- and nano-fabrication procedures. Further, acquisition of diverse sample types requires complex preparation procedures that limits SERS to lab-based applications. Recent innovations using plasmonic nanoparticles embedded in flexible paper substrates has allowed the expansion of SERS techniques to portable analytical procedures. Recently inkjet-printing has been identified as a low cost, rapid, and highly customizable method for producing paper based SERS sensors with robust performance. This chapter details the materials and procedures by which inkjet printed SERS sensors can be fabricated and applied to relevant applications. In particular, methods for utilizing the sensors for detection of antibiotics are presented.
表面增强拉曼光谱（SERS）可对小分子分析物进行快速、灵敏的识别。传统上，SERS设备的制造是一个昂贵的过程，涉及微纳制造工艺。此外，获取不同类型的样品需要复杂的制备程序，这限制了SERS仅用于基于实验室的应用。最近，将等离子体纳米颗粒嵌入柔性纸质基底的创新方法使得SERS技术得以扩展到便携式分析程序。最近，喷墨打印已被视为一种低成本、快速且高度可定制的方法，用于生产性能稳健的纸质SERS传感器。本章详细介绍了喷墨打印SERS传感器的制造材料和程序，以及如何将其应用于相关领域。特别介绍了利用这些传感器检测抗生素的方法。
