Oba Takaaki, Maeno Kazuma, Ono Mayu, Iesato Asumi, Ito Tokiko, Kanai Toshiharu, Mochizuki Yasuhiro, Ito Ken-Ichi, Yoshizawa Akihiko, Takayama Fumiyoshi
Division of Breast, Endocrine and Respiratory Surgery, Department of Surgery, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
Division of Laboratory Medicine, Shinshu University Hospital, Matsumoto, Japan.
Breast J. 2017 Mar;23(2):220-224. doi: 10.1111/tbj.12715. Epub 2016 Nov 7.
An adenomyoepithelioma of the breast is a rare tumor characterized by biphasic proliferation of both epithelial and myoepithelial cells. This tumor is generally considered as a benign neoplasm, and there are few reports describing the imaging features of this tumor through F-fluorodeoxyglucose positron emission tomography (FDG-PET). Here, we report a case of an adenomyoepithelioma that showed strong uptake of FDG on PET similar to that observed with a malignant tumor. A 73-year-old woman presented to our hospital with a 3.5-cm, mobile, and elastic hard tumor in the upper area of the left breast. Although the findings of mammography, ultrasonography, and contrast-enhanced magnetic resonance imaging suggested that the tumor was malignant, it was diagnosed as an adenomyoepithelioma by core needle biopsy. An invasive ductal carcinoma, 0.5-cm in size, was detected in the medial upper area of the ipsilateral breast during an examination. Although FDG-PET demonstrated no lymph node or distant metastases from the invasive ductal carcinoma, strong uptake of FDG was detected in the adenomyoepithelioma. Breast conserving surgery and sentinel lymph node biopsy for the invasive ductal carcinoma together with resection of the adenomyoepithelioma was performed. A diagnosis of adenomyoepithelioma was confirmed through histologic examination of the resected specimen. This case indicates that some adenomyoepitheliomas may show a strong uptake of FDG on PET, which resembles a malignant tumor.
乳腺腺肌上皮瘤是一种罕见肿瘤，其特征为上皮细胞和肌上皮细胞的双相增殖。该肿瘤通常被认为是良性肿瘤，很少有报告描述通过F-氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）对这种肿瘤的影像学特征。在此，我们报告一例腺肌上皮瘤，其在PET上显示出与恶性肿瘤相似的FDG强烈摄取。一名73岁女性因左乳上部出现一个3.5厘米大小、可活动且质地硬韧的肿瘤前来我院就诊。尽管乳腺X线摄影、超声检查及对比增强磁共振成像结果提示该肿瘤为恶性，但经粗针活检诊断为腺肌上皮瘤。在检查过程中，于同侧乳腺内侧上部检测到一个大小为0.5厘米的浸润性导管癌。尽管FDG-PET显示浸润性导管癌无淋巴结或远处转移，但在腺肌上皮瘤中检测到FDG强烈摄取。对浸润性导管癌进行了保乳手术及前哨淋巴结活检，并同时切除了腺肌上皮瘤。通过对切除标本的组织学检查证实了腺肌上皮瘤的诊断。该病例表明，一些腺肌上皮瘤在PET上可能显示出与恶性肿瘤相似的FDG强烈摄取。
