Krishtal O A, Osipchuk Y V, Shelest T N, Smirnoff S V
Bogomoletz Institute of Physiology, Ukrainian Academy of Sciences, Kiev, U.S.S.R.
Brain Res. 1987 Dec 15;436(2):352-6. doi: 10.1016/0006-8993(87)91678-7.
Extracellular pH changes were measured in the rat hippocampal slices using the pH-sensitive dye Phenol red. pH changes accompanied artificially evoked synaptic transmission in the dendrite area of dentate gyrus neurones and pyramidal neurones (CA1). Single electrical stimulation of presynaptic pathways produced a rapid acidic pH shift which was followed by a long-lasting alkaline one. The duration (nearly 10 ms) and amplitude of the acidic shift were closely related to the orthodromically evoked population excitatory postsynaptic potential. Population action potential, when elicited antidromically or in conditions of blocked synaptic transmission, did not produce any pH changes which are supposed to be specifically linked to the synaptic transmission.
使用pH敏感染料酚红测量大鼠海马切片中的细胞外pH变化。pH变化伴随着在齿状回神经元和锥体神经元（CA1）树突区域人工诱发的突触传递。对突触前通路进行单次电刺激会产生快速的酸性pH偏移，随后是持久的碱性偏移。酸性偏移的持续时间（近10毫秒）和幅度与顺向诱发的群体兴奋性突触后电位密切相关。当通过逆向刺激或在突触传递受阻的条件下诱发群体动作电位时，不会产生任何假定与突触传递特异性相关的pH变化。
