雌激素对人血浆中多巴胺、去甲肾上腺素及β-内啡肽样免疫反应性无影响。

Absence of effect of estrogen on dopamine, norepinephrine and beta-endorphin-like immunoreactivity in human plasma.

作者信息

Miyake A, Nishizaki T, Ohtsuka S, Yoshimoto Y, Aono T, Tanizawa O

机构信息

Department of Obstetrics and Gynecology, Osaka School of Medicine, Japan.

出版信息

Endocrinol Jpn. 1987 Oct;34(5):789-92. doi: 10.1507/endocrj1954.34.789.

DOI:10.1507/endocrj1954.34.789

PMID:2830102

Abstract

The plasma concentrations of immunoreactive norepinephrine (NE), dopamine (DA), beta-endorphin (beta-E), luteinizing hormone (LH) and follicle stimulating hormone (FSH) were determined by RIA and HPLC every 6 h until 72 h after iv administration of conjugated estrogens during the midfollicular phase. The LH level showed a biphasic pattern after the injection of conjugated estrogens, i.e. significant suppression (-50%) for 6-42 h after the injection, followed by a rebound increase with a peak (+85%) at 72 h. The plasma levels of immunoreactive beta-E, NE and DA did not change significantly for 72 h after the injection.

摘要

在卵泡中期静脉注射结合雌激素后，每6小时通过放射免疫分析法（RIA）和高效液相色谱法（HPLC）测定一次免疫反应性去甲肾上腺素（NE）、多巴胺（DA）、β-内啡肽（β-E）、促黄体生成素（LH）和促卵泡激素（FSH）的血浆浓度，直至72小时。注射结合雌激素后，LH水平呈双相模式，即注射后6-42小时显著抑制（-50%），随后在72小时出现反弹增加，峰值为（+85%）。注射后72小时，免疫反应性β-E、NE和DA的血浆水平无显著变化。