Vigo Alessandro, Costagliola Giulia, Ferrero Elisa, Noce Silvia
a Department of Paediatrics , Center for Pediatric Sleep Medicine and SIDS, Regina Margherita Children's Hospital, Città della Salute e della Scienza , Turin , Italy.
Hum Vaccin Immunother. 2017 Jun 3;13(6):1-4. doi: 10.1080/21645515.2017.1287642. Epub 2017 Feb 21.
Hypotonic-hyporesponsive (HHE) episodes are known and recognized phenomena, which typically occur within 48 hours of immunisation..Our aim is to describe 12 cases of HHE brought to the Center of Pediatric Sleep Medicine, with attention to the clinical features of the episode and their follow-up. Medical charts of infants visited between 2005-2015 were reviewed. Twelve infants showed a HHE using HHE using Brighton Collaboration Criteria. All infants received a Hexavalent diphtheria -tetanus -pertussis acellular component -hepatitis B-,inactivated poliovirus- Haemophilus influenzae type-b conjugate vaccine. Five out of 12 were brought to Emergency Department, where 2 were symptomatic (one was hyporeactive, the other had fever). No infant died during the episode, or the follow-up, nor developed neurological disease after subsequent vaccinations. HHE are confirmed as benign events, even after administration of hexavalent vaccination, devoid of negative neuropsychomotor outcome.
低渗性低反应（HHE）发作是已知且被认可的现象，通常发生在免疫接种后48小时内。我们的目的是描述12例带到儿科睡眠医学中心的HHE病例，关注发作的临床特征及其随访情况。回顾了2005年至2015年间就诊婴儿的病历。12名婴儿根据布莱顿协作标准显示为HHE。所有婴儿均接种了六价白喉-破伤风-无细胞百日咳成分-乙型肝炎-灭活脊髓灰质炎病毒-b型流感嗜血杆菌结合疫苗。12例中有5例被送往急诊科，其中2例有症状（1例反应低下，另1例发热）。发作期间或随访期间无婴儿死亡，后续接种疫苗后也未发生神经系统疾病。即使在接种六价疫苗后，HHE也被确认为良性事件，不会产生负面的神经心理运动结果。
