Palayoor S T, Seyfried T N
Department of Neurology, Yale University School of Medicine, New Haven, Connecticut.
Exp Neurol. 1988 Mar;99(3):768-71. doi: 10.1016/0014-4886(88)90191-4.
Total, Mg2+-, Na+,K+-, and Ca2+-ATPase activities were studied in fresh brain membrane preparations from adult epileptic (El) mice and nonepileptic C57BL/6J (B6) mice. The El mice have an inherited type of temporal lobe epilepsy. No significant differences were observed between the El and B6 mice for any of the ATPase activities in the hippocampus, brain stem, or cerebellum. These findings indicate that seizure susceptibility in El mice is not associated with differences in the activities of these cationic ATPases and that seizure susceptibility in El mice and audiogenic DBA/2 mice may involve different biochemical mechanisms.
在成年癫痫（El）小鼠和非癫痫C57BL/6J（B6）小鼠的新鲜脑膜制剂中研究了总Mg2 +、Na +、K +和Ca2 + -ATP酶活性。El小鼠患有遗传性颞叶癫痫。在海马体、脑干或小脑中，El小鼠和B6小鼠的任何一种ATP酶活性均未观察到显著差异。这些发现表明，El小鼠的癫痫易感性与这些阳离子ATP酶活性的差异无关，并且El小鼠和听源性DBA/2小鼠的癫痫易感性可能涉及不同的生化机制。
