利用精氨酸甲基化再生肌肉。
Regenerating muscle with arginine methylation.
作者信息
Blanc Roméo S, Richard Stéphane
机构信息
a Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital , Montréal , Québec , Canada.
b Departments of Oncology and Medicine , McGill University , Montréal , Québec , Canada.
出版信息
Transcription. 2017 May 27;8(3):175-178. doi: 10.1080/21541264.2017.1291083. Epub 2017 Feb 17.
Abstract
Protein arginine methyltransferase (PRMT) is a family of nine proteins catalyzing the methylation of arginine residues. They were recently shown to be essential for proper regeneration of skeletal muscles. However, the mechanisms triggering the methylation event, as well as how the methylated substrates regulate muscle stem cell function and fate decision remain to be determined. This point-of-view will discuss the recent findings on the specific role of PRMT1, CARM1/PRMT4, PRMT5, and PRMT7 in muscle stem cell fate guidance, and shed light on the future challenges which could help defining the therapeutic potential of PRMT inhibitors against muscular disorders and aging.
摘要
蛋白质精氨酸甲基转移酶（PRMT）是一个由九种蛋白质组成的家族，可催化精氨酸残基的甲基化。最近研究表明，它们对于骨骼肌的正常再生至关重要。然而，引发甲基化事件的机制，以及甲基化底物如何调节肌肉干细胞功能和命运决定仍有待确定。本观点将讨论PRMT1、CARM1/PRMT4、PRMT5和PRMT7在肌肉干细胞命运引导中的特定作用的最新发现，并阐明未来的挑战，这些挑战可能有助于确定PRMT抑制剂针对肌肉疾病和衰老的治疗潜力。
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Arginine Methylation: The Coming of Age.精氨酸甲基化：崭露头角。
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