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The concept of isoreceptors: application to the nicotinic acetylcholine receptor and the gamma-aminobutyric acidA/benzodiazepine receptor complex.

作者信息

Hebebrand J, Friedl W, Propping P

机构信息

Institute of Human Genetics, University of Bonn, Federal Republic of Germany.

出版信息

J Neural Transm. 1988;71(1):1-9. doi: 10.1007/BF01259405.

DOI:10.1007/BF01259405
PMID:2830362
Abstract

The concept of isoreceptors offers a possible clue to account for pharmacological and biochemical heterogeneity in specific receptor systems. The existence of isozymes has set the foundation for the definition of isoreceptors. The resulting criteria are applied to two central receptor complexes. Accordingly, the nicotinic acetylcholine receptor is defined as an isoreceptor, and research results on the GABA/benzodiazepine receptor are interpreted under the consideration of the possible existence of isoreceptors.

摘要

相似文献

1
The concept of isoreceptors: application to the nicotinic acetylcholine receptor and the gamma-aminobutyric acidA/benzodiazepine receptor complex.
J Neural Transm. 1988;71(1):1-9. doi: 10.1007/BF01259405.
2
Pharmacological subtypes of the gamma-aminobutyric acidA receptors defined by a gamma-aminobutyric acid analogue 4,5,6,7-tetrahydroisoxazolo[5,4-c] pyridin-3-ol and allosteric coupling: characterization using subunit-specific antibodies.由γ-氨基丁酸类似物4,5,6,7-四氢异恶唑并[5,4-c]吡啶-3-醇定义的γ-氨基丁酸A受体的药理学亚型及变构偶联:使用亚基特异性抗体进行表征
Mol Pharmacol. 1995 Oct;48(4):666-75.
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4
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[GABA(A) benzodiazepine receptors and epilepsy].[γ-氨基丁酸A(GABA(A))苯二氮䓬受体与癫痫]
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Mapping the location of functional nicotinic and gamma-aminobutyric acidA receptors on hippocampal neurons.绘制海马神经元上功能性烟碱和γ-氨基丁酸A受体的位置。
J Pharmacol Exp Ther. 1996 Dec;279(3):1491-506.

引用本文的文献

1
Early developmental exposure to benzodiazepine ligands alters brain levels of thiobarbituric acid-reactive products in young adult rats.早年接触苯二氮䓬配体可改变成年幼鼠大脑中硫代巴比妥酸反应产物的水平。
Neurochem Res. 1989 Nov;14(11):1119-27. doi: 10.1007/BF00965618.

本文引用的文献

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MULTIPLE FORMS OF ENZYMES: TISSUE, ONTOGENETIC, AND SPECIES SPECIFIC PATTERNS.酶的多种形式:组织、个体发育和物种特异性模式。
Proc Natl Acad Sci U S A. 1959 May;45(5):753-63. doi: 10.1073/pnas.45.5.753.
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Acetylcholine receptor: complex of homologous subunits.乙酰胆碱受体:同源亚基复合体。
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A gamma-aminobutyric acid/benzodiazepine receptor complex of bovine cerebral cortex.牛大脑皮层的γ-氨基丁酸/苯二氮䓬受体复合物
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[3H]Propyl beta-carboline-3-carboxylate as a selective radioligand for the BZ1 benzodiazepine receptor subclass.[3H]丙基β-咔啉-3-羧酸酯作为BZ1苯二氮䓬受体亚类的选择性放射性配体。
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Differential ontogeny of type 1 and type 2 benzodiazepine receptors.
Life Sci. 1981 May 21;28(21):2343-7. doi: 10.1016/0024-3205(81)90498-7.
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Molecular heterogeneity of benzodiazepine receptors.苯二氮䓬受体的分子异质性
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Ontogenetic changes in GABA modulation of brain benzodiazepine binding.γ-氨基丁酸(GABA)对脑苯二氮䓬结合的个体发育变化
Neuropharmacology. 1980 Apr;19(4):405-8. doi: 10.1016/0028-3908(80)90193-8.
8
Photoaffinity labeling of different benzodiazepine receptors at physiological temperature.生理温度下不同苯二氮䓬受体的光亲和标记
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9
Biochemical pharmacology of the gamma-aminobutyric acid receptor/ionophore protein.γ-氨基丁酸受体/离子载体蛋白的生化药理学
Fed Proc. 1984 Oct;43(13):2773-8.
10
Isoenzymes, multiple enzyme forms, and phylogeny.同工酶、多种酶形式与系统发育。
Adv Comp Physiol Biochem. 1974;5(0):109-95. doi: 10.1016/b978-0-12-011505-1.50009-8.