Wingbermühle Robin, Wen Ke-Xin, Wolters Frank J, Ikram M Arfan, Bos Daniel
Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
Department of Neurology, Erasmus MC, Rotterdam, The Netherlands.
J Alzheimers Dis. 2017;57(4):1191-1195. doi: 10.3233/JAD-170063.
The association of smoking with preclinical cognitive decline remains unclear and may be modified by the APOEɛ4 genotype. In 5,705 participants (mean age: 63.9±9.1 years; 57.4% women) from the population-based Rotterdam Study, we investigated the relationship between smoking and cognitive decline over a 5.5-year period and examined potential effect modification by APOEɛ4 genotype. We found that current smoking was related to decline in global cognition [difference compared to never smoking: -0.06 (95% C.I.-0.10;-0.01)], as well as decline on specific cognitive tests including the Letter Digit Substitution Task, the 15-Word Learning Test, and the Purdue Pegboard. We found no evidence for effect modification by APOEɛ4 genotype on this relation.
吸烟与临床前认知衰退之间的关联仍不明确，且可能会受到APOEɛ4基因型的影响。在基于人群的鹿特丹研究的5705名参与者（平均年龄：63.9±9.1岁；57.4%为女性）中，我们调查了5.5年期间吸烟与认知衰退之间的关系，并研究了APOEɛ4基因型的潜在效应修饰作用。我们发现，当前吸烟与整体认知衰退有关[与从不吸烟相比的差异：-0.06（95%置信区间-0.10；-0.01）]，以及在包括字母数字替换任务、15词学习测试和普渡钉板测试在内的特定认知测试中的衰退。我们没有发现APOEɛ4基因型对这种关系有效应修饰作用的证据。
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