Wang Jie-Yu, Zhang Li, Liu Jia, Yang Wei, Ma Li-Na
Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Medicine, Beijing 100053, China.
World J Clin Cases. 2021 Feb 16;9(5):1005-1015. doi: 10.12998/wjcc.v9.i5.1005.
Metabolic syndrome (MetS) is related to poor cognitive function. However, the results of previous studies were inconsistent, and whether the allele modifies the association remains unclear.
To elucidate the relationships among MetS, , and cognitive dysfunction in an elderly population in China.
One hundred elderly patients with MetS and 102 age- and gender-matched controls were included in the study. Baseline clinical characteristics and biochemical index for glucose and lipid metabolism were obtained. The distribution of was assessed with PCR restriction fragment length polymorphism analysis. Cognitive function was evaluated by mini-mental status examination at the 1-year follow-up examination.
Compared with controls, MetS patients had worse cognitive function and decreased ability to participate in activities of daily life ( = 0.001 and 0.046, respectively). Patients with cognitive dysfunction had higher prevalence of MetS (62.1% 36.4%, < 0.001) and were more likely to carry the allele (22.3% 10.1%, = 0.019). Multivariate logistic regression analyses showed that diagnosis with MetS, severe insulin resistance, status as an carrier, higher systolic blood pressure, and larger waist circumference were risk factors for cognitive dysfunction ( < 0.05). Repeated-measures analysis of variance, performed with data collected at the 1-year follow-up, revealed continuous influences of MetS and on the deterioration of cognitive function (time × team, < 0.001 for both).
Diagnosis of MetS and carrier status were persistently associated with cognitive dysfunction among an elderly population in China.
代谢综合征（MetS）与认知功能差有关。然而，先前研究的结果并不一致，且该等位基因是否会改变这种关联仍不清楚。
阐明中国老年人群中代谢综合征、该等位基因与认知功能障碍之间的关系。
本研究纳入了100例老年代谢综合征患者和102例年龄及性别匹配的对照。获取了基线临床特征以及糖脂代谢的生化指标。采用聚合酶链反应-限制性片段长度多态性分析评估该等位基因的分布。在1年随访检查时通过简易精神状态检查表评估认知功能。
与对照组相比，代谢综合征患者的认知功能更差，参与日常生活活动的能力下降（分别为P = 0.001和0.046）。认知功能障碍患者中代谢综合征的患病率更高（62.1% 对36.4%，P < 0.001），且更有可能携带该等位基因（22.3% 对10.1%，P = 0.019）。多因素逻辑回归分析显示，代谢综合征诊断、严重胰岛素抵抗、该等位基因携带者状态、较高的收缩压和较大的腰围是认知功能障碍的危险因素（P < 0.05）。对1年随访收集的数据进行重复测量方差分析，结果显示代谢综合征和该等位基因对认知功能恶化存在持续影响（时间×组别，两者P均< 0.001）。
在中国老年人群中，代谢综合征诊断和该等位基因携带者状态与认知功能障碍持续相关。
