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从大鼠脑组织中分离出对二氢吡啶结合位点和电压依赖性Ca2+摄取的抑制活性。

Isolation from rat brain tissue of an inhibiting activity for dihydropyridine binding sites and voltage-dependent CA2+ uptake.

作者信息

Sanna E, Hanbauer I

机构信息

Hypertension-Endocrine Branch, NHLBI National Institutes of Health, Bethesda, MD 20892.

出版信息

Neuropharmacology. 1987 Dec;26(12):1811-4. doi: 10.1016/0028-3908(87)90140-7.

DOI:10.1016/0028-3908(87)90140-7
PMID:2830557
Abstract

Nitrendipine binding-inhibitory activity was extracted and partially purified from rat brain. This preparation also decreased veratridine-stimulated Ca2+ uptake in cultured cerebellar granule cells. It failed to inhibit 3H-nitrendipine binding by sequestering Ca2+ that is required for the high affinity binding of nitrendipine. An allosteric modulation of nitrendipine recognition sites by this preparation is suggested.

摘要

尼群地平结合抑制活性从大鼠脑中提取并部分纯化。该制剂还降低了培养的小脑颗粒细胞中藜芦碱刺激的钙离子摄取。它未能通过螯合尼群地平高亲和力结合所需的钙离子来抑制3H-尼群地平结合。提示该制剂对尼群地平识别位点有别构调节作用。

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