Cayrol Christian, Deparis Pierre
Centre de Biologie du Développement, U.A. CNRS no. 0675, Université Paul Sabatier, 118 route de Narbonne, F-31062, Toulouse Cedex, France.
Rouxs Arch Dev Biol. 1987 Apr;196(4):257-261. doi: 10.1007/BF00376350.
In the newt, Pleurodeles waltli, vitellogenin synthesis can be induced by oestrogen prior to metamorphosis and well before vitellogenin synthesis is normally observed in females. Vitellogenin indicubility has been shown to occur during normal development at stage 53 in both sexes. Immersion of young larvae in thyroxine at concentrations that did not result in early morphological metamorphosis led to a precocious acquisition of liver responsiveness to oestrogen. Treatment of larvae with thiourea greatly diminished the ability of oestradiol to induce vitellogenin synthesis, although it did not abolish the hormonal response.
在蝾螈（Pleurodeles waltli）中，雌激素可在变态前且远早于雌性正常出现卵黄蛋白原合成之前诱导卵黄蛋白原的合成。已表明在两性的正常发育阶段53时都会出现卵黄蛋白原不溶性。将幼体幼虫浸入甲状腺素中，浓度未导致早期形态变态，但却导致肝脏对雌激素的反应性早熟。用硫脲处理幼虫极大地降低了雌二醇诱导卵黄蛋白原合成的能力，尽管它并未消除激素反应。
