Meller W, Kathol R G, Jaeckle R S, Grambsch P, Lopez J F
Department of Psychiatry, University of Iowa Hospitals, Iowa City 52242.
Am J Psychiatry. 1988 Mar;145(3):318-24. doi: 10.1176/ajp.145.3.318.
In order to identify depressed patients with hypothalamic-pituitary-adrenal (HPA) axis abnormalities who have a normal response to the dexamethasone suppression test (DST), the authors administered a series of neuroendocrine tests including insulin-induced hypoglycemia, arginine vasopressin challenge, and a DST. Using standard sensitivity measures, as well as logistic regression, they concluded that many patients with HPA abnormalities are not identified by the DST. These findings suggest that other neuroendocrine tests, which are sensitive to HPA axis abnormalities, may be helpful in subtyping depression on the basis of HPA axis functioning.
为了识别下丘脑-垂体-肾上腺（HPA）轴异常但对地塞米松抑制试验（DST）反应正常的抑郁症患者，作者进行了一系列神经内分泌测试，包括胰岛素诱发低血糖、精氨酸加压素激发试验和DST。使用标准敏感性测量方法以及逻辑回归分析，他们得出结论，许多HPA轴异常的患者无法通过DST识别出来。这些发现表明，其他对HPA轴异常敏感的神经内分泌测试，可能有助于根据HPA轴功能对抑郁症进行亚型分类。
