Ziegler V, Kipping D, Herrmann K, Haustein U F, Löschke K
Klinik für Hautkrankheiten, Karl-Marx-Universität, Leipzig.
Derm Beruf Umwelt. 1987 Nov-Dec;35(6):199-204.
Next to oxygen silicium is the most common substance of our environment. It occurs mostly in form of quartz (SiO2). In the past silica was usually mentioned in connection with foreign body granulomas in dermatological papers. Recently relations between occupational silica exposure and several diseases were reported. Silica exposure was related to the development of scleroderma, lupus erythematodes and sarcoidosis. Pathogenetic connections may be due to a stimulating effect on fibroblasts and due to immunmodulating properties of silica.
除了氧之外，硅是我们环境中最常见的物质。它大多以石英（SiO₂）的形式存在。过去，在皮肤科文献中，二氧化硅通常与异物肉芽肿相关联被提及。最近，有报道称职业性接触二氧化硅与多种疾病之间存在关联。接触二氧化硅与硬皮病、红斑狼疮和结节病的发展有关。发病机制上的联系可能是由于对成纤维细胞的刺激作用以及二氧化硅的免疫调节特性。
