Nauseef W M
Division of Infectious Disease, University of Iowa, Iowa City.
Hematol Oncol Clin North Am. 1988 Mar;2(1):135-58.
MPO activity is critical for optimal microbicidal activity of normal PMNs. In the absence of MPO, auxiliary mechanisms protect most MPO-deficient hosts from clinically significant sequelae, except for some persons with diabetes mellitus who suffer severe candidal disease. However, given our limited knowledge of the clinical impact of MPO deficiency, histochemical staining of peripheral blood smears or MPO activity of isolated leukocytes should be assessed in patients with unexplained fungal disease or with suspected impaired host defenses. Recently isolated cDNA probes provide important tools for dissecting the molecular and cell biology underlying hereditary MPO deficiency and the link between MPO gene expression and myeloid differentiation.
髓过氧化物酶（MPO）活性对于正常中性粒细胞的最佳杀菌活性至关重要。在缺乏MPO的情况下，辅助机制可保护大多数MPO缺乏的宿主免于出现具有临床意义的后遗症，但患有严重念珠菌病的糖尿病患者除外。然而，鉴于我们对MPO缺乏的临床影响了解有限，对于患有不明原因的真菌病或疑似宿主防御功能受损的患者，应评估外周血涂片的组织化学染色或分离白细胞的MPO活性。最近分离出的cDNA探针为剖析遗传性MPO缺乏的分子和细胞生物学以及MPO基因表达与髓系分化之间的联系提供了重要工具。
