Cardiology Department, Stavanger University Hospital, Stavanger, Norway.
Sandnes kommune, Norway.
Scand J Med Sci Sports. 2018 Jan;28(1):172-179. doi: 10.1111/sms.12878. Epub 2017 Apr 12.
C-reactive protein (CRP) increases after strenuous exercise. It has been a concern that prolonged strenuous exercise may be harmful and induce a deleterious inflammatory response. The purpose of this study was to (a) assess and quantify the magnitude of CRP response following an endurance cycling competition in healthy middle-aged recreational cyclists. (b) Identify important determinants of this response. (c) Identify the relationship between CRP, myocardial damage (cardiac Troponin I (cTnI)), and myocardial strain (B-type natriuretic peptide [BNP]). (d) Identify the relationship between CRP and clinical events, defined as utilization of healthcare services or self-reported unusual discomfort. Race time was used as a measure of physical fitness. A total of 97 individuals (43±10 years of age, 74 [76%] males) were assessed prior to and 0, 3, and 24 hours following the 91-km mountain bike race "Nordsjørittet" (Sandnes, Norway, June 2013). There was a highly significant increase in CRP from baseline to 24 hours (0.9 (0.5-1.8) mg/L vs. 11.6 (6.0-17.5) mg/L (median[IQR]), P<.001), with no correlation of CRP to cTnI and BNP at any time-point. CRP was strongly correlated to race time at baseline (r=.38, P<.001) and at 24 hours following the race (r=.43, P<.001), In multivariate models, race time was an independent predictor of CRP both at baseline and at 24 hours (P<.01). There was no relationship between CRP levels and clinical events. In conclusion, high physical fitness was associated with reduction in both basal- and exercise-induced CRP. No adverse relationship was found between high intensity physical exercise, CRP levels, and outcomes.
C 反应蛋白（CRP）在剧烈运动后会升高。人们一直担心长时间的剧烈运动可能有害，并引发有害的炎症反应。本研究的目的是：（a）评估和量化健康中年休闲自行车运动员在一次耐力自行车比赛后 CRP 反应的幅度。（b）确定这种反应的重要决定因素。（c）确定 CRP 与心肌损伤（心肌肌钙蛋白 I（cTnI））和心肌应变（B 型利钠肽[BNP]）之间的关系。（d）确定 CRP 与临床事件的关系，定义为使用医疗保健服务或自我报告的异常不适。比赛时间用作身体适应性的衡量标准。共有 97 名个体（43±10 岁，74 [76%] 男性）在参加 91 公里山地自行车比赛“Nordsjørittet”（挪威桑讷斯，2013 年 6 月）之前和之后的 0、3 和 24 小时进行了评估。CRP 从基线到 24 小时显著升高（0.9（0.5-1.8）mg/L 与 11.6（6.0-17.5）mg/L（中位数[IQR]），P<.001），CRP 与 cTnI 和 BNP 之间没有任何时间点的相关性。CRP 与基线时的比赛时间（r=.38，P<.001）和比赛后 24 小时（r=.43，P<.001）呈强烈相关。在多变量模型中，比赛时间是基线和 24 小时后 CRP 的独立预测因子（P<.01）。CRP 水平与临床事件之间没有关系。总之，高身体适应性与降低基础和运动诱导的 CRP 有关。高强度体力活动、CRP 水平和结果之间没有不良关系。
