血管抑制素-1作为头颈部鳞状细胞癌的一种新型预后因素
Vasohibin-1 as a Novel Prognostic Factor for Head and Neck Squamous Cell Carcinoma.
作者信息
Torii Chisaho, Hida Yasuhiro, Shindoh Masanobu, Akiyama Kosuke, Ohga Noritaka, Maishi Nako, Ohiro Yoichi, Ono Mitsunobu, Totsuka Yasunori, Kitagawa Yoshimasa, Tei Kanchu, Sato Yasufumi, Hida Kyoko
机构信息
Vascular Biology, Frontier Research Unit, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan.
Department of Oral and Maxillofacial Surgery, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan.
出版信息
Anticancer Res. 2017 Mar;37(3):1219-1225. doi: 10.21873/anticanres.11437.
AIM
We evaluated the prognostic value of vasohibin-1 (VASH1) expression in head and neck squamous cell carcinoma.
MATERIALS AND METHODS
Immunohistochemistry for VASH1 and cluster of differentiation 34 (CD34) was performed on 61 head and neck squamous cell carcinoma specimens. The association between VASH1 expression in the tumour and clinical outcomes was analyzed statistically.
RESULTS
VASH1 staining in normal tissue adjacent to cancerous tissue was negative, whereas it was positive in tumour blood vessels and AE1/AE3 and Ki67-positive tumour cells. Therefore, we examined the association between VASH1 expression in the tumour and clinical outcomes. Patients with high VASH1 expression in tumour had significantly shorter disease-free survival and more frequently had lymph node recurrence than those with low VASH1 expression.
CONCLUSION
These results suggest that VASH1 expression is associated with tumour progression and may be useful as a prognostic marker of head and neck squamous cell carcinoma.
目的
我们评估了血管抑制素-1（VASH1）表达在头颈部鳞状细胞癌中的预后价值。
材料与方法
对61例头颈部鳞状细胞癌标本进行VASH1和分化簇34（CD34）的免疫组织化学检测。对肿瘤中VASH1表达与临床结局之间的关联进行统计学分析。
结果
癌旁正常组织中的VASH1染色为阴性，而在肿瘤血管以及AE1/AE3和Ki67阳性的肿瘤细胞中呈阳性。因此，我们研究了肿瘤中VASH1表达与临床结局之间的关联。肿瘤中VASH1高表达的患者无病生存期明显较短，且淋巴结复发的频率高于VASH1低表达的患者。
结论
这些结果表明，VASH1表达与肿瘤进展相关，可能作为头颈部鳞状细胞癌的预后标志物。
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