Arachidonic acid-induced pleurisy (ARIP): an in vivo model for testing 5-lipoxygenase inhibition.
作者信息
Boctor A M, Burke C, Hovinga M E
机构信息
Department of Pharmacology, Warner-Lambert/Parke-Davis Pharmaceutical Research, Ann Arbor, Michigan.
出版信息
Methods Find Exp Clin Pharmacol. 1987 Dec;9(12):793-7.
PMID:2831442
Abstract
Arachidonic acid-induced pleurisy in the rat was evaluated for testing inhibitors of arachidonic acid (AA) metabolism. The model involves the administration of AA intrapleurally and the determination of LTB4 and PGE2 as indicators of 5-lipoxygenase and cyclooxygenase activities in the exudate/wash. This model is suitable for the in vivo evaluation of potential inhibitors of the 5-lipoxygenase pathway but not the cyclooxygenase pathway of AA cascade.
摘要
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