Larkin Derek, Martin Colin R
School of Psychology, Edge Hill University, L39 4QP Ormskirk, Lancashire, UK.
Faculty of Society and Health, Buckinghamshire New University, UB8 1NA Uxbridge, UK.
Neurophysiol Clin. 2017 Apr;47(2):123-129. doi: 10.1016/j.neucli.2017.01.012. Epub 2017 Mar 15.
The chronic fatigue syndrome (CFS) remains a contentious and controversial presentation despite decades of systematic research from a variety of medical specialties and associated disciplines. Variously championed as a condition of immunological, neurological, neurophysiological, psychiatric or psychological origin, consensus on a cogent and evidenced-based pathway has yet to be achieved. Irrespective of the ambiguity regarding aetiology, what is incontrovertible is the experience of significant depression, which often accompanies this most distressing clinical presentation. The current paper examines the potential underlying mechanisms, which may determine and explain this relationship between CFS and depression. In doing so, it offers some insights, which may be of value in the development of evidence-based and scientifically-anchored interventions in individuals experiencing this diagnosis, to improve outcomes in relation to depression specifically and quality of life more generally.
尽管来自多个医学专业和相关学科进行了数十年的系统研究，但慢性疲劳综合征（CFS）仍然是一个有争议的临床表现。它被不同地认为起源于免疫、神经、神经生理、精神或心理等方面，但尚未就一个有说服力且基于证据的发病机制达成共识。无论病因存在何种模糊性，无可争议的是，严重抑郁的体验常常伴随着这种最令人痛苦的临床表现。本文探讨了可能决定和解释CFS与抑郁之间这种关系的潜在机制。在此过程中，它提供了一些见解，这对于为患有这种病症的个体制定基于证据且有科学依据的干预措施可能具有价值，以特别改善抑郁状况，并更全面地提高生活质量。
