Jones Oliver, Gooding Richard
University Hospitals of Leicester NHS Trust, Leicester, UK.
BMJ Case Rep. 2017 Mar 17;2017:bcr2016218919. doi: 10.1136/bcr-2016-218919.
A young woman developed a line-associated deep vein thrombosis (DVT), which was treated with low molecular weight heparin (dalteparin). 8 days later, the DVT had significantly extended-in spite of therapeutic heparin levels. A diagnosis of heparin-induced thrombocytopenia and thrombosis (HITT) was considered, but the platelet count had not dropped. Nevertheless, a HITT assay was carried out which came back positive, with a repeat assay confirming the result. Dalteparin was stopped and apixaban treatment started, with symptomatic recovery over the following days and weeks.
一名年轻女性发生了与导管相关的深静脉血栓形成(DVT),接受了低分子量肝素(达肝素)治疗。8天后,尽管肝素水平处于治疗范围,但DVT仍显著扩展。考虑诊断为肝素诱导的血小板减少症和血栓形成(HITT),但血小板计数并未下降。尽管如此,仍进行了HITT检测,结果呈阳性,重复检测证实了该结果。停用达肝素并开始阿哌沙班治疗,随后数天至数周症状逐渐恢复。