靶向刺猬信号通路的抗癌药物研发。
Development of anticancer agents targeting the Hedgehog signaling.
作者信息
Zhang Xiangqian, Tian Ye, Yang Yanling, Hao Jijun
机构信息
College of Life Science, Yan'an University, Yan'an, 716000, Shaanxi, China.
Medical College, Yan'an University, Yan'an, 716000, Shaanxi, China.
出版信息
Cell Mol Life Sci. 2017 Aug;74(15):2773-2782. doi: 10.1007/s00018-017-2497-x. Epub 2017 Mar 17.
Abstract
Hedgehog signaling is an evolutionarily conserved pathway which is essential in embryonic and postnatal development as well as adult organ homeostasis. Abnormal regulation of Hedgehog signaling is implicated in many diseases including cancer. Consequently, substantial efforts have made in the past to develop potential therapeutic agents that specifically target the Hedgehog signaling for cancer treatment. Here, we review the therapeutic agents for inhibition of the Hedgehog signaling and their clinical advances in cancer treatment.
摘要
刺猬信号通路是一条在进化上保守的信号通路，在胚胎发育、出生后发育以及成体器官稳态维持中至关重要。刺猬信号通路的异常调控与包括癌症在内的多种疾病相关。因此，过去人们付出了巨大努力来开发特异性靶向刺猬信号通路用于癌症治疗的潜在治疗药物。在此，我们综述了抑制刺猬信号通路的治疗药物及其在癌症治疗中的临床进展。
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ACS Chem Biol. 2016 Dec 16;11(12):3256-3262. doi: 10.1021/acschembio.6b00896. Epub 2016 Oct 25.
2
The hedgehog pathway in triple-negative breast cancer.三阴性乳腺癌中的刺猬信号通路。
Cancer Med. 2016 Oct;5(10):2989-3006. doi: 10.1002/cam4.833. Epub 2016 Aug 18.
3
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4
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