西格玛受体简介：它们在疾病中的作用及作为治疗靶点的情况。

Introduction to Sigma Receptors: Their Role in Disease and as Therapeutic Targets.

作者信息

Smith Sylvia B

机构信息

Departments of Cellular Biology and Anatomy and Ophthalmology and the James and Jean Culver Vision Discovery Institute, Medical College of Georgia at Augusta University, Augusta, GA, 30912, USA.

出版信息

Adv Exp Med Biol. 2017;964:1-4. doi: 10.1007/978-3-319-50174-1_1.

DOI:10.1007/978-3-319-50174-1_1

PMID:28315260

Abstract

This book highlights contributions from leaders in the field of sigma receptor research. Sigma receptors represent a promising, novel target for the treatment of neurodegenerative diseases, retinal degenerations, pain and substance abuse. Information is presented about tracers for molecular imaging these receptors, the newly determined crystal structure of human sigma 1 receptor and information about sigma 2 receptor. New discoveries about the role of sigma 1 receptors in cancer, pain, neuropsychiatric disorders, learning and memory, neuronal networks and depression are described. The compendium offers important insights about the direction unfolding for this exciting field of research.

摘要

本书重点介绍了西格玛受体研究领域领军人物的贡献。西格玛受体是治疗神经退行性疾病、视网膜退行性病变、疼痛和药物滥用的一个有前景的新靶点。书中介绍了用于这些受体分子成像的示踪剂、新测定的人西格玛1受体晶体结构以及西格玛2受体的相关信息。还描述了西格玛1受体在癌症、疼痛、神经精神疾病、学习与记忆、神经网络和抑郁症中的作用的新发现。该论文集为这个令人兴奋的研究领域的发展方向提供了重要见解。