Portillas Rusticio, Turner Barbara, Jeffers Audrey, Chen Lee-Lynn, Champagne Mary
University of California, San Francisco (UCSF) Medical Center.
Duke University.
Clin J Oncol Nurs. 2017 Apr 1;21(2):E49-E53. doi: 10.1188/17.CJON.E49-E53.
BACKGROUND: Life-threatening toxicity may result from administration of high-dose (HD) interleukin-2 (IL-2). Patients receiving HD IL-2 treatment often experience severe adverse side effects, which result in the interruption of treatment. .
OBJECTIVES: A standardized order set (SOS) was developed for patients with melanoma or renal cell carcinoma receiving HD IL-2. The aims of the study were to determine compliance of clinicians to the SOS, report the completed doses and major side effects of HD IL-2, and document the satisfaction level of clinicians. .
METHODS: A retrospective chart review of 40 health records of patients with melanoma or renal cell carcinoma who were treated with HD IL-2 was conducted to determine compliance to the SOS. Staff satisfaction with the SOS was surveyed. .
The SOS was successfully implemented with a provider compliance rate of 90%. Cardiovascular side effects were the most common. Clinicians found the SOS very satisfactory or superior in guiding care and treatment of side effects.
高剂量（HD）白细胞介素-2（IL-2）给药可能导致危及生命的毒性反应。接受HD IL-2治疗的患者常出现严重的不良副作用，从而导致治疗中断。
为接受HD IL-2治疗的黑色素瘤或肾细胞癌患者制定了标准化医嘱集（SOS）。该研究的目的是确定临床医生对SOS的依从性，报告HD IL-2的完成剂量和主要副作用，并记录临床医生的满意度。
对40例接受HD IL-2治疗的黑色素瘤或肾细胞癌患者的健康记录进行回顾性图表审查，以确定对SOS的依从性。对工作人员对SOS的满意度进行了调查。
SOS成功实施，提供者依从率为90%。心血管副作用最为常见。临床医生发现SOS在指导护理和副作用治疗方面非常令人满意或优于其他方案。
