Zygula Aleksandra, Szymusik Iwona, Grzechocinska Barbara, Marianowski Piotr, Wielgos Miroslaw
1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Poland.
Neuro Endocrinol Lett. 2016 Nov;37(6):419-426.
Implantation failure is one of the major factors limiting success of in vitro fertilization (IVF) treatment. According to ESHRE 2009 data only 32% of fresh embryo transfers resulted in clinical pregnancies. There are many ideas to improve the treatment outcomes, endometrial injury being one of them. It has been suggested that local endometrial injury, performed either by pipelle biopsy or hysteroscopy, may increase clinical pregnancy rate. However, up to date literature is widely disparate on that subject. There is no conclusion with regard to optimal timing, the number and technique of the procedure. The following paper is the review of the evidence from clinical studies dealing with the effect of endometrial injury on the IVF outcome to guide clinical practice for this challenging problem. PubMed, Embase, the Cochrane Library using Medical Subject Headings and free text terms were searched up to June 2016 without year restriction. Though the majority of trials showed positive impact of endometrial injury on IVF outcome, there is still a lack of strong evidence to support routine local endometrial injury in women prior to IVF treatment.
着床失败是限制体外受精（IVF）治疗成功率的主要因素之一。根据欧洲人类生殖与胚胎学会（ESHRE）2009年的数据，仅有32%的新鲜胚胎移植获得了临床妊娠。有许多改善治疗结局的方法，子宫内膜损伤就是其中之一。有人提出，通过吸管活检或宫腔镜检查进行的局部子宫内膜损伤可能会提高临床妊娠率。然而，目前关于该主题的文献差异很大。在最佳时机、手术次数和技术方面尚无定论。以下论文是对临床研究证据的综述，这些研究涉及子宫内膜损伤对IVF结局的影响，以指导针对这一具有挑战性问题的临床实践。截至2016年6月，对PubMed、Embase、Cochrane图书馆使用医学主题词和自由文本词进行了检索，无年份限制。尽管大多数试验显示子宫内膜损伤对IVF结局有积极影响，但仍缺乏有力证据支持在IVF治疗前对女性进行常规局部子宫内膜损伤。
