不同分娩方式对新生儿氧化应激的影响

Oxidative stress in newborns by different modes of delivery.

作者信息

Veleminsky Milos, Ambroz Antonin, Rossner Pavel, Rossnerova Andrea, Svecova Vlasta, Milcova Alena, Dostal Miroslav, Pastorkova Anna, Pulkrabova Jana, Hajslova Jana, Solansky Ivo, Hanzl Milan, Sram Radim J

机构信息

Faculty of Health and Social Studies, South Bohemian University, Ceske Budejovice, Czech Republic.

Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic.

出版信息

Neuro Endocrinol Lett. 2016 Nov;37(6):445-451.

PMID:28315629

Abstract

OBJECTIVES

The aim of our study is to investigate the impact of the type of delivery - vaginal vs. cesarean section on oxidative damage determined as the lipid peroxidation (15-F2t-isoprostane (15-F2t-IsoP) in the cord blood of newborns and venous blood from mothers in two localities with different levels of air pollution: Ceske Budejovice (CB), a locality with a clean air, and Karvina, a locality with high air pollution.

RESUTLS

In Karvina, the concentration of PM2.5 was higher than in CB in the summer 2013 (mean±SD: 20.41±6.28 vs. 9.45±3.62 µg/m3, p<0.001) and in the winter 2014 (mean±SD: 53.67±19.76 vs. 27.96±12.34 µg/m3, p<0.001). Similarly, the concentration of B[a]P was higher in Karvina than in CB in the summer 2013 (mean±SD: 1.16±0.91 vs. 0.16±0.26 ng/m3, p<0.001) and in the winter 2014 (5.36±3.64 vs. 1.45±1.19 ng/m3, p<0.001). Delivery procedures differed by the type of anesthesia; at the Cesarean section in CB was used general anesthesia in 73.8% vs. 20.8% in Karvina (p<0.001), epidural anesthesia in CB in 26.2% vs. 77.1% in Karvina (p<0.001), at vaginal delivery was local anesthesia used in CB in 58.9% vs. 14.1% in Karvina (p<0.001). In CB was oxidative stress higher after vaginal delivery (101.7±31.0 pg 15-F2t-isoP/ml plasma) vs. Cesarean section (83.9±26.9 pg 15-F2t-isoP/ml plasma, p<0.001), no difference between the type of delivery was observed in Karvina.

CONCLUSION

No difference between the types of delivery was observed in mothers in CB as well as in Karvina. Oxidative stress in newborns in Karvina was significantly affected by the concentrations of PM2.5 and B[a]P in the polluted air.

摘要

目的

我们研究的目的是调查分娩方式——阴道分娩与剖宫产，对氧化损伤的影响，氧化损伤通过脂质过氧化作用来测定，即测定两个空气污染水平不同地区的新生儿脐带血和母亲静脉血中的15 - F2t -异前列腺素（15 - F2t - IsoP）：空气清洁的地区捷克布杰约维采（CB）和空气污染严重的地区卡尔维纳。

结果

在卡尔维纳，2013年夏季PM2.5的浓度高于CB（均值±标准差：20.41±6.28 vs. 9.45±3.62 μg/m³，p<0.001），2014年冬季也是如此（均值±标准差：53.67±19.76 vs. 27.96±12.34 μg/m³，p<0.001）。同样，2013年夏季卡尔维纳的苯并[a]芘浓度高于CB（均值±标准差：1.16±0.91 vs. 0.16±0.26 ng/m³，p<0.001），2014年冬季（5.36±3.64 vs. 1.45±1.19 ng/m³，p<0.001）。分娩方式因麻醉类型而异；在CB剖宫产时73.8%使用全身麻醉，而在卡尔维纳为20.8%（p<0.001），CB剖宫产时26.2%使用硬膜外麻醉，卡尔维纳为77.1%（p<0.001），阴道分娩时CB 58.9%使用局部麻醉，卡尔维纳为14.1%（p<0.001）。在CB，阴道分娩后的氧化应激高于剖宫产（101.7±31.0 pg 15 - F2t -异前列腺素/毫升血浆）（83.9±26.9 pg 15 - F2t -异前列腺素/毫升血浆，p<0.001），在卡尔维纳未观察到分娩方式之间的差异。