Wehrmann W, Niedecken H, Bauer R
Universitäts-Hautklinik und Poliklinik Bonn.
Z Hautkr. 1987;62 Suppl 1:111-5.
The metabolism of essential unsaturated fatty acids seems to show changes in patients with atopic dermatitis (AD). A defect or a deficiency of a Delta-6-Desaturase, which transforms cis-linoleic acid into gamma-linolenic-acid will be discussed. We examined the influence of a treatment with unsaturated fatty acids on clinical phenotype and the surface antigens of lymphocytes in peripheral blood. Prolonged recurrence free intervals as well as a faster ability to control relapse were established. Dysbalance in the lymphocytic system was able to be positively influenced. We found an increase of Leu 2 a-antigen carrying T-suppressor-lymphocytes and of the Leu 3+8+- antigen carrying subpopulation of T-helper-lymphocytes, which are responsible for activation of precursor T-suppressor cells into.
特应性皮炎（AD）患者体内必需不饱和脂肪酸的代谢似乎出现了变化。本文将探讨一种将顺式亚油酸转化为γ-亚麻酸的Δ-6-去饱和酶的缺陷或缺乏。我们研究了不饱和脂肪酸治疗对临床表型及外周血淋巴细胞表面抗原的影响。结果显示治疗后无复发间期延长，且控制复发的能力加快。淋巴细胞系统的失衡得到了积极改善。我们发现携带Leu 2 a抗原的T抑制淋巴细胞以及携带Leu 3 + 8 +抗原的T辅助淋巴细胞亚群有所增加，而T辅助淋巴细胞亚群负责将前体T抑制细胞激活。
