Nguyen Van Tuyen, Sorokina Elena A, Listratova Anna V, Voskressensky Leonid G, Lobanov Nikolai N, Dorovatovskii Pavel V, Zubavichus Yan V, Khrustalev Victor N
Institute of Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Hanoi, Vietnam; Graduate University of Science and Technology, 18 Hoang Quoc Viet, Hanoi, Vietnam.
Organic Chemistry Department, Peoples' Friendship University of Russia, 6 Miklukho-Maklaya St., Moscow 117198, Russian Federation.
Acta Crystallogr E Crystallogr Commun. 2017 Feb 7;73(Pt 3):338-340. doi: 10.1107/S205698901700161X. eCollection 2017 Mar 1.
The title compound, CHNO, is the product of a ring-expansion reaction from a seven-membered hexa-hydro-azepine to a nine-membered azonine. The azonine ring of the mol-ecule adopts a chair-boat conformation. In the crystal, mol-ecules are linked by bifurcated N-H⋯(O,O) hydrogen bonds, generating [010] zigzag chains. The title compound shows inhibitory activity against acetyl-cholinesterase and butyrylcholinesterase, and might be considered as a candidate for the design of new types of anti-Alzheimer's drugs.
标题化合物CHNO是由七元六氢氮杂䓬经扩环反应生成的九元氮杂环壬烷的产物。分子中的氮杂环壬烷环呈椅式-船式构象。在晶体中，分子通过分叉的N-H⋯(O,O)氢键相连，形成[010]之字形链。标题化合物对乙酰胆碱酯酶和丁酰胆碱酯酶具有抑制活性，可被视为新型抗阿尔茨海默病药物设计的候选物。
