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肾移植患者的类圆线虫超感染:时刻警惕

Strongyloides Hyperinfection in a Renal Transplant Patient: Always Be on the Lookout.

作者信息

Mazhar Murtaza, Ali Ijlal Akbar, Agudelo Higuita Nelson Iván

机构信息

Department of Internal Medicine, Suite 6300, 800 Stanton L Young Boulevard, Oklahoma University Health Sciences Center, Oklahoma City, OK 73104, USA.

Department of Infectious Diseases, Suite 7300, 800 Stanton L Young Boulevard, Oklahoma University Health Sciences Center, Oklahoma City, OK 73104, USA.

出版信息

Case Rep Infect Dis. 2017;2017:2953805. doi: 10.1155/2017/2953805. Epub 2017 Feb 20.

Abstract

We present a case of a 71-year-old Vietnamese man with chronic kidney disease secondary to adult polycystic kidney disease. He had been a prisoner of war before undergoing a successful cadaveric renal transplant in the United States. He presented to clinic one year after the transplant with gross hematuria, productive cough, intermittent chills, and weight loss. Long standing peripheral eosinophilia of 600-1200/L triggered further evaluation. A wet mount of stool revealed larvae. A computed tomography (CT) of chest showed findings suggestive of extension of the infection to the lungs. The patient was treated with a three-week course of ivermectin with complete resolution of signs, symptoms, peripheral eosinophilia, and the positive IgG serology. Strongyloides infection in renal transplant patient is very rare and often presents with hyperinfection, associated with high mortality rates. The American Transplant Society recommends pretransplant screening with stool examination and antibody in recipients and donors from endemic areas or with eosinophilia. It is imperative that healthcare professionals involved in the care of these individuals be cognizant of these recommendations as it is a very preventable and treatable entity.

摘要

我们报告一例71岁的越南男性患者,其患有继发于成人多囊肾病的慢性肾脏病。他曾是一名战俘,之后在美国接受了成功的尸体肾移植。移植术后一年,他因肉眼血尿、咳痰、间歇性寒战和体重减轻就诊。长期存在的外周血嗜酸性粒细胞增多,计数为600 - 1200/L,促使进一步评估。粪便湿片检查发现了幼虫。胸部计算机断层扫描(CT)显示有提示感染蔓延至肺部的表现。患者接受了为期三周的伊维菌素治疗,体征、症状、外周血嗜酸性粒细胞增多及IgG血清学阳性均完全消退。肾移植患者中的类圆线虫感染非常罕见,且常表现为播散性感染,死亡率很高。美国移植学会建议对来自流行地区或有嗜酸性粒细胞增多的受者和供者进行移植前粪便检查和抗体筛查。参与这些患者护理的医护人员必须了解这些建议,因为这是一个非常可预防和可治疗的疾病。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4215/5337848/2ad7e2529faf/CRIID2017-2953805.001.jpg

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