Brambilla F, Zarattini F, Gianelli A, Bianchi M, Panerai A
Ospedale Psichiatrico Pini, Milano, Italy.
Acta Psychiatr Scand. 1988 Jan;77(1):63-6. doi: 10.1111/j.1600-0447.1988.tb05078.x.
Beta-endorphin (beta-EP) and beta-lipotropin (beta-LPH) plasma concentrations were examined in ten chronic alcohol abusers, eight men and two women aged 25-56 years with histories of continuously elevated ethanol consumption dating from 5-30 years. Plasma levels of the two peptides were measured after acute alcohol consumption and then after 3, 6 and 9 days of forced abstinence, during chlordiazepoxide treatment. Beta-EP and beta-LPH concentrations were normal on all four occasions. A reduced sensitivity of opioid receptors to acute alcohol administration due to chronic alcohol consumption is suggested.
对10名慢性酒精滥用者进行了β-内啡肽（β-EP）和β-促脂素（β-LPH）血浆浓度检测，其中8名男性和2名女性，年龄在25至56岁之间，有5至30年持续高乙醇摄入量的病史。在急性饮酒后，然后在氯氮卓治疗期间强制戒酒3、6和9天后，测量这两种肽的血浆水平。在所有这四个时间点，β-EP和β-LPH浓度均正常。提示由于慢性酒精摄入，阿片受体对急性酒精给药的敏感性降低。
