Mohammed H, Coates M, Masterson L, Chan W Y, Hassan Y, Nassif R
Department of Otolaryngology-Head and Neck Surgery, Norfolk and Norwich University Hospital, Norwich, UK.
Clin Otolaryngol. 2017 Dec;42(6):1311-1318. doi: 10.1111/coa.12872. Epub 2017 Apr 18.
To explore the rationale for investigating patients presenting with globus symptoms. In this regard, we also assess the efficacy and safety of transnasal flexible laryngo-oesophagoscopy (TNFLO).
A prospective study in a head and neck cancer centre of patients with persistent globus symptoms with normal flexible nasoendoscopy/indirect mirror laryngoscopy and failure of first-line medical treatment. The role of TNFLO in investigating these patients was assessed.
A total of 218 patients were recruited in this study. Positive findings included upper aerodigestive cancers in two patients, other pathologies included reflux (four patients), cricopharyngeus-related pathologies (19 patients), candida (five patients). There were only five re-referrals of patients who were discharged following normal examination with TNFLO. In nine patients, TNFLO could not be completed and they went on to have other diagnostic procedures CONCLUSION: This article is the largest to date in the UK to assess the role of TNFLO in investigating patients with globus symptoms. TNFLO is equal to rigid endoscopy as a diagnostic tool. However, it is superior in terms of image clarity, ability to record video images and safety.
探讨对有咽异感症症状患者进行检查的理论依据。在此方面，我们还评估了经鼻柔性喉食管镜检查（TNFLO）的有效性和安全性。
在一家头颈癌中心对持续性咽异感症症状患者进行前瞻性研究，这些患者的柔性鼻内镜检查/间接喉镜检查结果正常且一线药物治疗无效。评估了TNFLO在检查这些患者中的作用。
本研究共纳入218例患者。阳性发现包括2例上消化道癌，其他病变包括反流（4例）、环咽肌相关病变（19例）、念珠菌感染（5例）。经TNFLO检查正常后出院的患者中只有5例再次转诊。9例患者无法完成TNFLO检查，他们继而接受了其他诊断程序。结论：本文是英国迄今为止评估TNFLO在检查咽异感症症状患者中作用的最大规模研究。TNFLO作为一种诊断工具与硬质内镜相当。然而，它在图像清晰度、记录视频图像的能力和安全性方面更具优势。
