Xenoulis Panagiotis G, Steiner Jörg M
Clinic of Medicine, Faculty of Veterinary Medicine, University of Thessaly, Karditsa, Greece; Animal Medical Center of Athens, Athens, Greece.
Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
Top Companion Anim Med. 2016 Dec;31(4):134-139. doi: 10.1053/j.tcam.2016.10.005. Epub 2016 Oct 31.
A clinical diagnosis of pancreatitis in dogs and cats can be challenging. Several diagnostic modalities have been evaluated over the years for the diagnosis of canine and feline pancreatitis, but most of these modalities have been shown to be of limited clinical use because of poor performance, limited availability, or because they are invasive, or all of these. Assays for the measurement of pancreatic lipase (PL) immunoreactivity [Specific canine PL (Spec cPL) in dogs and Specific feline PL (Spec fPL) in cats] were first developed approximately 15 years ago, and studies have shown that they are currently the serum tests of choice for the evaluation of canine and feline patients, respectively, suspected of having pancreatitis. This is a direct consequence of their high specificity of detecting only PL and their sensitivity for pancreatitis when compared with other serum tests. SNAP cPL and SNAP fPL are in-clinic tests that have been developed based on the Spec cPL and Spec fPL assays. As with any other test, false-positive and false-negative results do occur with PL immunoreactivity assays, and it is important to know the limitations of these assays.
犬猫胰腺炎的临床诊断可能具有挑战性。多年来，人们评估了多种诊断方法用于犬猫胰腺炎的诊断，但由于性能不佳、可用性有限、具有侵入性或兼而有之，这些方法大多在临床应用中受到限制。大约15年前首次开发了用于测量胰腺脂肪酶（PL）免疫反应性的检测方法（犬的特异性犬PL（Spec cPL）和猫的特异性猫PL（Spec fPL）），研究表明，它们目前分别是评估疑似患有胰腺炎的犬猫患者的首选血清检测方法。与其他血清检测相比，这是它们仅检测PL的高特异性及其对胰腺炎的敏感性的直接结果。SNAP cPL和SNAP fPL是基于Spec cPL和Spec fPL检测方法开发的临床检测方法。与任何其他检测一样，PL免疫反应性检测确实会出现假阳性和假阴性结果，了解这些检测方法的局限性很重要。
