妊娠期膜增生性肾小球肾炎
Membranoproliferative Glomerulonephritis in Pregnancy.
作者信息
Nair Devika, Kidd Laura, Krane N Kevin
机构信息
Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana; Department of Pathology, Tulane University School of Medicine, New Orleans, Louisiana.
Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana.
出版信息
Am J Med Sci. 2017 Apr;353(4):320-328. doi: 10.1016/j.amjms.2017.01.007. Epub 2017 Jan 31.
BACKGROUND
Membranoproliferative glomerulonephritis (MPGN) is an uncommon form of glomerulonephritis and it can be particularly difficult to predict outcomes and manage women with this disorder during pregnancy.
MATERIALS AND METHODS
The management of 3 successful pregnancies in women with MPGN from 1 center and previously described cases from the world literature are reviewed. This includes a number of large studies of pregnancy in women with underlying glomerular disease as well as small case series and individual reports. Courses of these pregnancies, maternal and fetal outcomes, and management, when described, were included in this review.
RESULTS
Some successful outcomes used antiplatelet therapy and plasmapheresis, but high-dose intravenous, followed by oral, corticosteroid therapy was used most frequently in patients with successful outcomes.
CONCLUSIONS
The data provided is meant as a guide for clinicians who provide care for women with MPGN who are considering pregnancy or women who present with this disorder while pregnant.
背景
膜增生性肾小球肾炎（MPGN）是一种少见的肾小球肾炎形式，在孕期预测患有这种疾病的女性的预后并对其进行管理可能特别困难。
材料与方法
回顾了来自1个中心的3例患有MPGN的女性成功妊娠的管理情况以及世界文献中先前描述的病例。这包括一些对患有潜在肾小球疾病的女性妊娠情况的大型研究以及小型病例系列和个案报告。这些妊娠的过程、母婴结局以及所描述的管理情况均纳入本综述。
结果
一些成功的结局采用了抗血小板治疗和血浆置换，但在结局成功的患者中最常使用的是大剂量静脉注射，随后口服皮质类固醇治疗。
结论
所提供的数据旨在为那些为考虑妊娠的患有MPGN的女性或孕期出现这种疾病的女性提供护理的临床医生提供指导。
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