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器官捐献者管理:八项值得反思的常见建议和行动。

Organ donor management: Eight common recommendations and actions that deserve reflection.

机构信息

Servicio de Medicina Intensiva, HU Puerta de Hierro-Majadahonda, Majadahonda, Madrid, Spain.

Servicio de Medicina Crítica, HU San José TEC Salud, Monterrey, N.L., Mexico.

出版信息

Med Intensiva. 2017 Dec;41(9):559-568. doi: 10.1016/j.medin.2017.01.012. Epub 2017 Mar 16.

Abstract

Despite major advances in our understanding of the physiopathology of brain death (BD), there are important controversies as to which protocol is the most appropriate for organ donor management. Many recent reviews on this subject offer recommendations that are sometimes contradictory and in some cases are not applied to other critically ill patients. This article offers a review of the publications (many of them recent) with an impact upon these controversial measures and which can help to confirm, refute or open new areas of research into the most appropriate measures for the management of organ donors in BD, and which should contribute to discard certain established recommendations based on preconceived ideas, that lead to actions lacking a physiopathological basis. Aspects such as catecholamine storm management, use of vasoactive drugs, hemodynamic objectives and monitoring, assessment of the heart for donation, and general care of the donor in BD are reviewed.

摘要

尽管我们对脑死亡(BD)的病理生理学有了重大的认识进展,但在哪个方案最适合器官捐献者管理方面仍存在重要争议。许多关于这个主题的最新评论提供的建议有时是相互矛盾的,在某些情况下不适用于其他重症患者。本文回顾了一些具有影响力的出版物(其中许多是最近的),这些出版物涉及到这些有争议的措施,并有助于证实、反驳或开辟新的研究领域,以确定 BD 中最适合器官捐献者管理的措施,这应该有助于摒弃基于先入为主观念的某些既定建议,这些观念导致缺乏病理生理基础的行动。本文还回顾了一些方面,如儿茶酚胺风暴管理、血管活性药物的使用、血流动力学目标和监测、供心的评估以及 BD 中供体的一般护理。

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