Doss J G, Ghani W M N, Razak I A, Yang Y H, Rogers S N, Zain R B
Department of Community Oral Health and Clinical Prevention, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia; Oral Cancer Research and Coordinating Centre (OCRCC), Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia.
Oral Cancer Research and Coordinating Centre (OCRCC), Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia.
Int J Oral Maxillofac Surg. 2017 Jun;46(6):687-698. doi: 10.1016/j.ijom.2017.02.1269. Epub 2017 Mar 16.
This study aimed to assess changes in oral cancer patients' health-related quality of life (HRQOL) and the impact of disease stage on HRQOL scores. HRQOL data were collected from seven hospital-based centres using the Functional Assessment of Cancer Therapy-Head and Neck (FACT-H&N) version 4.0 instrument. The independent samples t-test, χ test, and paired samples t-test were used to analyse the data. A total of 300 patients were recruited. The most common oral cancer sub-site was tongue and floor of mouth (42.6%). Surgical intervention (41.1%) was the most common treatment modality. Significant differences in ethnicity and treatment modality were observed between early and late stage patients. Pre-treatment HRQOL scores were significantly lower for late than early stage patients. At 1 month post-treatment, the functional and head and neck domains and the FACT-H&N (TOI) summary scores showed significant deterioration in both early and late stage patients. In contrast, the emotional domain showed a significant improvement for early and late stage patients at 1, 3, and 6 months post-treatment. Although HRQOL deterioration was still observed among early and late stage patients at 6 months post-treatment, this was not statistically significant. In conclusion, advanced disease is associated with poorer HRQOL. Although ethnic differences were observed across different disease stages, the influence of ethnicity on patient HRQOL was not evident in this study.
本研究旨在评估口腔癌患者健康相关生活质量（HRQOL）的变化以及疾病分期对HRQOL评分的影响。使用癌症治疗功能评估-头颈（FACT-H&N）第4.0版工具从七个医院中心收集HRQOL数据。采用独立样本t检验、χ检验和配对样本t检验对数据进行分析。共招募了300名患者。最常见的口腔癌亚部位是舌和口底（42.6%）。手术干预（41.1%）是最常见的治疗方式。早期和晚期患者在种族和治疗方式上存在显著差异。晚期患者治疗前的HRQOL评分显著低于早期患者。治疗后1个月，早期和晚期患者的功能、头颈领域以及FACT-H&N（TOI）总结评分均显示出显著恶化。相比之下，情感领域在治疗后1、3和6个月时，早期和晚期患者均显示出显著改善。尽管在治疗后6个月时，早期和晚期患者仍观察到HRQOL恶化，但这在统计学上并不显著。总之，疾病晚期与较差的HRQOL相关。尽管在不同疾病阶段观察到了种族差异，但在本研究中种族对患者HRQOL的影响并不明显。
