远端炔基迁移与光氧化还原催化协同促进非活化烯烃自由基三氟甲基化炔基化反应。
Merging Distal Alkynyl Migration and Photoredox Catalysis for Radical Trifluoromethylative Alkynylation of Unactivated Olefins.
机构信息
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 199 Ren-Ai Road, Suzhou, Jiangsu, 215123, China.
School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou, Guangdong, 510275, China.
出版信息
Angew Chem Int Ed Engl. 2017 Apr 10;56(16):4545-4548. doi: 10.1002/anie.201700413. Epub 2017 Mar 20.
Disclosed herein is a novel, redox-neutral protocol for the visible-light-induced radical alkynylation of unactivated olefins. The intramolecular migration of an alkynyl group, by cleaving an inert C-C σ bond, is realized for the first time. A wide range of synthetically useful trifluoroethylated linear alkynes are readily obtained under mild reaction conditions.
本文公开了一种新型的可见光诱导的未活化烯烃自由基炔基化的氧化还原中性反应方案。首次实现了通过切断惰性 C-C σ 键使炔基基团进行分子内迁移。在温和的反应条件下，很容易得到广泛的合成有用的三氟乙基化线性炔烃。
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