从开链葡萄糖构型的起始原料立体选择性全合成氧化脂质。
Stereoselective total synthesis of Oxylipin from open chain gluco-configured building block.
作者信息
Borkar Santosh Ramdas, Aidhen Indrapal Singh
机构信息
Department of Chemistry, Indian Institute of Technology Madras, Chennai 600036, India.
Department of Chemistry, Indian Institute of Technology Madras, Chennai 600036, India.
出版信息
Carbohydr Res. 2017 Apr 18;443-444:23-28. doi: 10.1016/j.carres.2017.03.002. Epub 2017 Mar 3.
PMID:28319683
Abstract
Total synthesis of naturally occurring Oxylipin has been achieved from open chain gluco-configured building block which is readily assembled from inexpensive and commercially available D-(+)-gluconolactone. Grignard reaction and Wittig olefination reactions are key steps for the requisite CC bond formation.
摘要
从开链葡萄糖构型的构建单元已实现了天然存在的氧化脂质的全合成，该构建单元可由廉价且市售的D-(+)-葡糖酸内酯轻松组装而成。格氏反应和维蒂希烯烃化反应是形成所需碳-碳键的关键步骤。
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